Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9197462 | 0.79 | GSK3B (0.47) | CYP1A2SMN1; SMN2GSK3BALDH1A1MAPT | |
| SCHEMBL30122758 | 0.71 | MAOA (0.45) | SMN1; SMN2GSK3BALDH1A1MAPTKMT2A | |
| SCHEMBL1890488 | 0.70 | CYP1A2 (0.39) | CYP1A2SMN1; SMN2GSK3BALDH1A1MAPT | |
| SCHEMBL20218242 | 0.68 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2GSK3BALDH1A1MAPT | |
| SCHEMBL22806019 | 0.68 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2GSK3BALDH1A1MAPT | |
| SCHEMBL2493976 | 0.68 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL29759335 | 0.68 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2GSK3BALDH1A1MAPT | |
| SCHEMBL20909640 | 0.68 | GSK3B (0.51) | CYP1A2SMN1; SMN2GSK3BALDH1A1MAPT | |
| SCHEMBL29605127 | 0.68 | GSK3B (0.47) | CYP1A2SMN1; SMN2GSK3BALDH1A1KMT2A | |
| SCHEMBL22428324 | 0.67 | TDP2 (0.52) | SMN1; SMN2GAAKMT2ATDP2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |