Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14597252 | 0.73 | TNKS2 (0.44) | GSK3BTNKS2CYP1A2SMN1; SMN2GAA | |
| SCHEMBL14765037 | 0.71 | GSK3B (0.76) | GSK3BTNKS2CYP1A2SMN1; SMN2GAA | |
| SCHEMBL19117741 | 0.70 | GSK3B (0.47) | GSK3BTNKS2CYP1A2SMN1; SMN2GAA | |
| SCHEMBL29361422 | 0.70 | GSK3B (0.47) | GSK3BTNKS2CYP1A2SMN1; SMN2GAA | |
| SCHEMBL13847518 | 0.70 | CREBBP (0.55) | GSK3BTNKS2ALDH1A1 | |
| SCHEMBL1252548 | 0.69 | GSK3B (0.54) | GSK3BTNKS2CYP1A2SMN1; SMN2 | |
| SCHEMBL1252551 | 0.69 | GSK3B (0.54) | GSK3BTNKS2CYP1A2SMN1; SMN2 | |
| SCHEMBL15823777 | 0.69 | GSK3B (0.46) | GSK3BTNKS2ALDH1A1 | |
| SCHEMBL8293271 | 0.68 | TSHR (0.48) | GSK3BTNKS2CYP1A2SMN1; SMN2KMT2A | |
| SCHEMBL3422239 | 0.68 | CYP1A2 (0.47) | GSK3BTNKS2CYP1A2SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | Prosetta Antiviral, Inc. | 2019-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190111044-A1 | 2-PHENETHENYLTETRAHYDRO ISOQUINOLINES USEFUL AS ANTI-HIV COMPOUNDS | MAVS, EIF2AK2, POLRMT | GSK3B 4151/4885TNKS2 136/4885CYP1A2 1713/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.