Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | DAO | P14920 | 3/20 | 0.53 |
| ▸ | FEN1 | P39748 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | DDO | Q99489 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7123791 | 0.79 | KEAP1 (0.54) | KDM4EDAOFEN1ALDH1A1GLA | |
| SCHEMBL17942038 | 0.78 | KDM4E (0.69) | KDM4EDAOALDH1A1DDOMAPT | |
| SCHEMBL9389777 | 0.77 | DAO (0.65) | KDM4EDAOFEN1ALDH1A1GLA | |
| SCHEMBL13708850 | 0.77 | GSK3B (0.54) | KDM4EDAOFEN1ALDH1A1GLA | |
| SCHEMBL6519610 | 0.76 | GSK3B (0.56) | KDM4EDAOFEN1ALDH1A1GLA | |
| SCHEMBL7114921 | 0.76 | DAO (0.46) | KDM4EDAOFEN1ALDH1A1GLA | |
| SCHEMBL7122354 | 0.76 | KDM5A (0.54) | KDM4EDAOFEN1ALDH1A1GAA | |
| SCHEMBL7124017 | 0.76 | KDM4E (0.46) | KDM4EDAOFEN1ALDH1A1KEAP1 | |
| SCHEMBL2151265 | 0.76 | PGR (0.68) | KDM4EDAOFEN1ALDH1A1GLA | |
| SCHEMBL5330425 | 0.74 | KDM4E (0.70) | KDM4EALDH1A1MAPTLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010058314-A1 | HYDROXYQUINOLIN-2(1H)-ONES AND DERIVATIVES THEREOF | PFIZER INC. (US) | 2010-05-27 | — | — | WO | disclosed |