Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.50 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HPGDS | O60760 | 2/20 | 0.45 |
| ▸ | TAOK1 | Q7L7X3 | 4/20 | 0.45 |
| ▸ | TAOK3 | Q9H2K8 | 4/20 | 0.45 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390877 | 1.00 | MTNR1A (0.50) | MTNR1AMTNR1BFAAHHDAC8HPGDS | |
| SCHEMBL3803983 | 0.93 | ALDH1A1 (0.47) | MTNR1AMTNR1BFAAHHPGDSGRM5 | |
| SCHEMBL28044904 | 0.82 | CYP3A4 (0.52) | FAAHHPGDS | |
| SCHEMBL3423083 | 0.82 | ALDH1A1 (0.61) | MTNR1AMTNR1BHDAC8TAOK1TAOK3 | |
| SCHEMBL3394258 | 0.82 | MTNR1A (0.60) | MTNR1AMTNR1BHDAC8TAOK1TAOK3 | |
| SCHEMBL6515277 | 0.82 | ALDH1A1 (0.61) | MTNR1AMTNR1BHDAC8TAOK1TAOK3 | |
| SCHEMBL3394439 | 0.82 | MTNR1A (0.60) | MTNR1AMTNR1BHDAC8TAOK1TAOK3 | |
| SCHEMBL4789249 | 0.80 | KCNH2 (0.56) | MTNR1AMTNR1BFAAHHPGDS | |
| SCHEMBL3391913 | 0.80 | GRM5 (0.52) | MTNR1AMTNR1BFAAHHDAC8TAOK1 | |
| SCHEMBL3393208 | 0.80 | GRM5 (0.52) | MTNR1AMTNR1BFAAHHDAC8TAOK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1370530-B1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-12-29 | — | — | EP | disclosed |
| US-6949556-B2 | Acylated 1,2,3,4-tetrahydronaphthyl amines and their use as pharmaceutical agents | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-09-27 | — | — | US | disclosed |
| EP-1370530-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | Aventis Pharma Deutschland GmbH (DE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002064565-A1 | ACYLATED 1,2,3,4-TETRAHYDRONAPHTHYL AMINES AND THEIR USE AS PHARMACEUTICAL | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-08-22 | — | — | WO | disclosed |