Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.54 |
| ▸ | CA9 | Q16790 | 12/20 | 0.54 |
| ▸ | CA1 | P00915 | 12/20 | 0.54 |
| ▸ | CA12 | O43570 | 11/20 | 0.54 |
| ▸ | CA5A | P35218 | 3/20 | 0.53 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.53 |
| ▸ | CA3 | P07451 | 1/20 | 0.53 |
| ▸ | CA6 | P23280 | 1/20 | 0.53 |
| ▸ | CA7 | P43166 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29179059 | 0.82 | CA1 (0.53) | CA2CA9CA1CA12CA5A | |
| SCHEMBL27729846 | 0.81 | PDPK1 (0.48) | CA2CA9CA1CA12CA5A | |
| SCHEMBL18850042 | 0.76 | MGLL (0.43) | MAPTNPSR1HSD17B10 | |
| SCHEMBL2771870 | 0.75 | CA2 (0.56) | CA2CA9CA1CA12CA5A | |
| SCHEMBL29179024 | 0.71 | CA1 (0.53) | CA2CA9CA1CA12CA5A | |
| P-Toluenesulfonamide SCHEMBL1331323 | 0.71 | CA2 (1.00) | CA2CA9CA1CA12CA5A | |
| P-Toluenesulfonamide SCHEMBL31527821 | 0.71 | CA2 (1.00) | CA2CA9CA1CA12CA5A | |
| P-Toluenesulfonamide SCHEMBL7370 | 0.71 | CA2 (1.00) | CA2CA9CA1CA12CA5A | |
| SCHEMBL19454426 | 0.71 | ACHE (0.44) | MAPTMAPK1 | |
| SCHEMBL13282020 | 0.70 | CA1 (0.56) | CA2CA9CA1CA12CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2224919-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS, AND TUMOR-RELATED DISORDERS | Tragara Pharmaceuticals, Inc. (US) | 2010-09-08 | — | — | EP | claimed |
| EP-2205075-A1 | THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND AROMATASE INHIBITORS OR COMBINATIONS OF COX-2 INHIBITORS AND ESTROGEN RECEPTOR ANTAGONISTS | Tragara Pharmaceuticals, Inc. (US) | 2010-07-14 | — | — | EP | claimed |
| EP-2170062-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS, AND TUMOR-RELATED DISORDERS | Tragara Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | claimed |
| WO-2009070546-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS, AND TUMOR-RELATED DISORDERS | TRAGARA PHARMACEUTICALS, INC. (US) | 2009-06-04 | — | — | WO | claimed |
| WO-2009042612-A1 | THERAPIES FOR TREATING CANCER USING COMBINATIONS OF COX-2 INHIBITORS AND AROMATASE INHIBITORS OR COMBINATIONS OF COX-2 INHIBITORS AND ESTROGEN RECEPTOR ANTAGONISTS | TRAGARA PHARMACEUTICALS, INC. (US) | 2009-04-02 | — | — | WO | claimed |
| WO-2009009778-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER, TUMORS, AND TUMOR-RELATED DISORDERS | TRAGARA PHARMACEUTICALS, INC. (US) | 2009-01-15 | — | — | WO | claimed |