Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 5/20 | 0.39 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105702 | 0.85 | PCSK9 (0.50) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL21452654 | 0.84 | MEN1 (0.44) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL4740871 | 0.84 | MEN1 (0.47) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL21452652 | 0.84 | MEN1 (0.44) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL6945578 | 0.84 | MEN1 (0.47) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL1262597 | 0.84 | MEN1 (0.47) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL4961848 | 0.84 | SYK (0.40) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL3421169 | 0.83 | MEN1 (0.44) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL1261059 | 0.83 | MEN1 (0.51) | CYP2D6MEN1GAAKMT2ACA2 | |
| SCHEMBL22730807 | 0.83 | MEN1 (0.41) | CYP2D6MEN1GAAKMT2ACA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9399639-B2 | Substituted azaindole compounds, salts, pharmaceutical compositions thereof and methods of use | CALITOR SCIENCES, LLC (US) | 2016-07-26 | — | — | US | disclosed |
| US-20140056849-A1 | SUBSTITUTED AZAINDOLE COMPOUNDS, SALTS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS OF USE | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-02-27 | — | — | US | disclosed |
| CN-102015699-A | Heterocyclic urea derivatives and methods of use thereof-211 | ASTRAZENECA AB | 2011-04-13 | — | — | CN | disclosed |
| WO-2010065709-A2 | HYDROXAMIC ACID DERIVATIVES, PREPARATION AND THERAPEUTIC USES THEREOF | KHAN AMIN (US) | 2010-06-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140056849-A1 | SUBSTITUTED AZAINDOLE COMPOUNDS, SALTS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS OF USE | TPMT, CYP3A5, AZI2 | CYP2D6 8/4885MEN1 351/4885GAA 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.