Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 5/20 | 0.39 |
| ▸ | ACACB | O00763 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6466785 | 0.82 | DRD2 (0.51) | DRD2PHGDHACACBMEN1KMT2A | |
| SCHEMBL19962315 | 0.80 | DRD2 (0.49) | DRD2PHGDHACACBMEN1KMT2A | |
| SCHEMBL19969739 | 0.80 | DRD2 (0.54) | DRD2PHGDHACACBKMT2A | |
| SCHEMBL4382315 | 0.78 | DRD2 (0.50) | DRD2ACACB | |
| SCHEMBL3450752 | 0.75 | KDM4E (0.49) | DRD2MAOBMAOA | |
| SCHEMBL30443592 | 0.75 | KDM4E (0.49) | DRD2MAOBMAOA | |
| SCHEMBL12852534 | 0.74 | MAOA (0.52) | DRD2PHGDHMAOBMAOAADRA2A | |
| SCHEMBL2930889 | 0.72 | PHGDH (0.50) | DRD2PHGDHACACBMEN1KMT2A | |
| SCHEMBL17124796 | 0.72 | PHGDH (0.44) | DRD2PHGDHMAOBACACBMEN1 | |
| SCHEMBL3398601 | 0.71 | ACACB (0.47) | DRD2PHGDHMAOBACACBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |