Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.41 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6259567 | 0.81 | RECQL (0.41) | MAPTRECQLPLIN1LMNAPLIN5 | |
| SCHEMBL6470886 | 0.81 | MAPT (0.40) | MAPTRECQLPLIN1LMNAPLIN5 | |
| SCHEMBL6259565 | 0.81 | RECQL (0.41) | MAPTRECQLPLIN1LMNAPLIN5 | |
| SCHEMBL3697930 | 0.81 | ALDH1A1 (0.42) | MAPTRECQLPLIN1LMNAPLIN5 | |
| SCHEMBL4896000 | 0.81 | MAPT (0.44) | MAPTRECQLPLIN1LMNAPLIN5 | |
| SCHEMBL7965919 | 0.79 | — | — | |
| SCHEMBL7965924 | 0.79 | — | — | |
| SCHEMBL28068774 | 0.78 | MAPT (0.38) | MAPTRECQLPLIN1LMNAPLIN5 | |
| SCHEMBL3472865 | 0.77 | AKT1 (0.42) | MAPTRECQLPLIN1LMNAPLIN5 | |
| SCHEMBL2492193 | 0.76 | MAPT (0.44) | MAPTRECQLPLIN1LMNAPLIN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111217690-B | Preparation method of propafenone hydrochloride and intermediate 2' -hydroxy dihydrochalcone thereof | 临沂大学（CN） | 2023-01-13 | — | — | CN | claimed |
| CN-105796548-A | Flavonoid drug composition and preparation method and application | 中国科学院西北高原生物研究所 | 2016-07-27 | — | — | CN | claimed |
| CN-111217690-B | Preparation method of propafenone hydrochloride and intermediate 2' -hydroxy dihydrochalcone thereof | 临沂大学（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-111217690-B | Preparation method of propafenone hydrochloride and intermediate 2' -hydroxy dihydrochalcone thereof | 临沂大学（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-111217690-B | Preparation method of propafenone hydrochloride and intermediate 2' -hydroxy dihydrochalcone thereof | 临沂大学（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-109310130-B | Cooling substance mixture | 西姆莱斯股份公司 | 2022-05-17 | — | — | CN | disclosed |
| CN-106459123-A | Novel substance mixture containing rubusoside or alpha-glucosyl rubusoside for improving sweetness | 西姆莱斯股份公司 | 2017-02-22 | — | — | CN | disclosed |
| CN-106063504-A | Aseptic cheese substrate | DMK德意志牛奶股份有限公司 | 2016-11-02 | — | — | CN | disclosed |
| US-9445606-B2 | Use of 4-hydroxydihydrochalcones and their salts for enhancing an impression of sweetness | SYMRISE AG (DE) | 2016-09-20 | — | — | US | disclosed |
| CN-105796548-A | Flavonoid drug composition and preparation method and application | 中国科学院西北高原生物研究所 | 2016-07-27 | — | — | CN | disclosed |
| CN-104886258-A | Protein mass to be used as a cheese substitute | DMK DEUTSCHES MILCHKONTOR GMBH | 2015-09-09 | — | — | CN | disclosed |
| CN-104719502-A | Use of laevulose for improving the sensorial properties of compositions based on acidic whey | DMK DEUTSCHES MILCHKONTOR GMBH | 2015-06-24 | — | — | CN | disclosed |
| US-20140135359-A1 | METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES | MARTINEAU LOUIS C (CA) | 2014-05-15 | — | — | US | disclosed |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2010-09-16 | — | — | US | disclosed |
| EP-1998636-B1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO KG (DE) | 2010-05-19 | — | — | EP | disclosed |
| US-20080317923-A1 | AROMA COMPOSITION FOR REDUCING OR SUPPRESSING AN UNDESIRED BITTER, ASTRINGENT IMPRESSION | SYMRISE GMBH & CO. KG (DE) | 2008-12-25 | — | — | US | disclosed |
| EP-1998636-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | Symrise GmbH & Co. KG (DE) | 2008-12-10 | — | — | EP | disclosed |
| CN-100418977-C | Fused heterocyclic derivative, pharmaceutical composition containing the same, and pharmaceutical use thereof | KISSEI PHARMACEUTICAL (JP) | 2008-09-17 | — | — | CN | disclosed |
| WO-2007107596-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | SYMRISE GMBH & CO. KG (DE) | 2007-09-27 | — | — | WO | disclosed |
| CN-1784415-A | Fused heterocyclic derivative, medicinal composition containing the same, and medicinal use thereof | KISSEI PHARMACEUTICAL (JP) | 2006-06-07 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135359-A1 | METHODS OF DESIGNING, PREPARING, AND USING NOVEL PROTONOPHORES | UQCRC2, UQCRC1, TIMM50 | MAPT 4702/4885RECQL 350/4885PLIN1 2923/4885 |
| US-20100233102-A1 | USE OF 4-HYDROXYDIHYDROCHALCONES AND THEIR SALTS FOR ENHANCING AN IMPRESSION OF SWEETNESS | TAS2R4, TAS2R1, TAS2R20 | MAPT 4633/4885RECQL 1133/4885PLIN1 2742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.