Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 11/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.47 |
| ▸ | DRD5 | P21918 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 8/20 | 0.47 |
| ▸ | HTR7 | P34969 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 5/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197948 | 0.99 | KDM4E (0.50) | KDM4EGAADRD2DRD3DRD5 | |
| SCHEMBL2194931 | 0.99 | KDM4E (0.47) | KDM4EGAADRD2DRD3DRD5 | |
| SCHEMBL4057154 | 0.98 | KDM4E (0.47) | KDM4EGAADRD2DRD3DRD5 | |
| SCHEMBL2196865 | 0.92 | HTR1A (0.47) | KDM4EGAADRD2DRD3DRD5 | |
| SCHEMBL1255683 | 0.88 | DRD2 (0.44) | KDM4EDRD2DRD3HTR1AHTR7 | |
| SCHEMBL1256145 | 0.88 | HTR1A (0.49) | KDM4EDRD2DRD3DRD5HTR1A | |
| SCHEMBL2197706 | 0.88 | KDM4E (0.48) | KDM4EDRD2DRD3HTR1AHTR2A | |
| SCHEMBL2191495 | 0.88 | ALDH1A1 (0.46) | KDM4EDRD2DRD3HTR1AHTR7 | |
| SCHEMBL2192247 | 0.88 | ALDH1A1 (0.46) | KDM4EDRD2DRD3HTR1AHTR7 | |
| SCHEMBL2195337 | 0.88 | SLC6A2 (0.43) | KDM4EDRD2DRD3HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2219648-A1 | TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | Cenomed Biosciences, LLC (US) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009062134-A1 | TREATMENT OF POST-TRAUMATIC STRESS DISORDER WITH TETRAHYDROINDOLONE ARYLPIPERAZINE COMPOUNDS | CENOMED BIOSCIENCES, LLC (US) | 2009-05-14 | — | — | WO | disclosed |