SCHEMBL3424438

SCHEMBL3424438

FC(F)(F)C(c1ccc(S)cc1)(c1ccc(S)cc1)C(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.56
ESR2 Q92731 1/20 0.56
TRPV4 Q9HBA0 1/20 0.36
IDO1 P14902 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14012082 0.91 ESR1 (0.48) ESR1ESR2TRPV4
SCHEMBL14464634 0.83 ESR1 (0.42) ESR1ESR2
SCHEMBL2092992 0.78 TRPV4 (0.36) ESR1ESR2TRPV4IDO1
SCHEMBL415546 0.77 ALDH1A1 (0.50) TRPV4IDO1
SCHEMBL11154793 0.74 TRPV4 (0.37) TRPV4IDO1
Fluoride SCHEMBL29094699 0.74 ALDH1A1 (0.48) TRPV4IDO1
SCHEMBL7929127 0.74 ESR1 (0.59) ESR1ESR2
SCHEMBL9475591 0.74 TRPV4 (0.33) ESR1ESR2TRPV4IDO1
SCHEMBL13154248 0.74 NR1H2 (0.56)
SCHEMBL3671873 0.72 ESR1 (0.56) ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111187187-A Preparation method of 2, 2-bis [4- (4-aminophenylsulfonyl) phenyl ] hexafluoropropane diamine monomer 桂林理工大学 2020-05-22 CN claimed
US-20090163692-A1 AROMATIC POLYETHERS GENERAL ELECTRIC COMPANY (US) 2009-06-25 US claimed
US-4720590-A [2,2,2-trihalo-1-(trihalomethyl)]ethylidene-bisbenzenethiols HUGHES AIRCRAFT COMPANY (US) 1988-01-19 US claimed
EP-0129561-B1 2,2,2-TRIHALO-1-(TRIHALOMETHYL)ETHYLIDENE-BISBENZENETHIOLS Hughes Aircraft Company (US) 1986-02-12 EP claimed
EP-0129561-A1 2,2,2-TRIHALO-1-(TRIHALOMETHYL)ETHYLIDENE-BISBENZENETHIOLS. HUGHES AIRCRAFT CO (US) 1985-01-02 EP claimed
WO-1984002524-A1 2,2,2-TRIHALO-1-(TRIHALOMETHYL)ETHYLIDENE-BISBENZENETHIOLS HUGHES AIRCRAFT CO (US) 1984-07-05 WO claimed
CN-111187187-A Preparation method of 2, 2-bis [4- (4-aminophenylsulfonyl) phenyl ] hexafluoropropane diamine monomer 桂林理工大学 2020-05-22 CN disclosed
EP-2209156-A1 Composite membrane and method for making General Electric Company (US) 2010-07-21 EP disclosed
US-20100167100-A1 COMPOSITE MEMBRANE AND METHOD FOR MAKING GENERAL ELECTRIC COMPANY 2010-07-01 US disclosed
JP-2006009026-A FLUORINE-CONTAINING ELASTOMER COMPOSITION YUNIMATEKKU KK 2006-01-12 JP disclosed
US-5998564-A CURING AGENT FOR FLUOROPOLYMERS NIPPON MEKTRON, LIMITED (JP) 1999-12-07 US disclosed
US-4866156-A Poly(arylether) or poly(arylthioether) from 2,2-bis(fluorophenyl)-hexafluoropropane HUGHES AIRCRAFT COPMANY (US) 1989-09-12 US disclosed
US-4827054-A Method for synthesizing 2,2-bis(4-fluorophenyl)-hexafluoropropane and method for using same to synthesize poly(arylethers) and poly (arylthioethers) HUGHES AIRCRAFT COMPANY (US) 1989-05-02 US disclosed
US-4708991-A Polymers of ethynylthiophenoxy derivatives of diphenylhexafluoropropane HUGHES AIRCRAFT COMPANY (US) 1987-11-24 US disclosed
US-4695655-A Ethynylthiophenoxy derivatives of diphenylhexafluoropropane HUGHES AIRCRAFT COMPANY (US) 1987-09-22 US disclosed
EP-0192766-A1 ETHYNYLPHENOXY AND ETHYNYLTHIOPHENOXY DERIVATIVES OF DIPHENYLHEXAFLUOROPROPANE. HUGHES AIRCRAFT CO (US) 1986-09-03 EP disclosed
WO-1986001504-A1 ETHYNYLPHENOXY AND ETHYNYLTHIOPHENOXY DERIVATIVES OF DIPHENYLHEXAFLUOROPROPANE HUGHES AIRCRAFT COMPANY (US) 1986-03-13 WO disclosed
EP-0129561-B1 2,2,2-TRIHALO-1-(TRIHALOMETHYL)ETHYLIDENE-BISBENZENETHIOLS Hughes Aircraft Company (US) 1986-02-12 EP disclosed
EP-0129561-A1 2,2,2-TRIHALO-1-(TRIHALOMETHYL)ETHYLIDENE-BISBENZENETHIOLS. HUGHES AIRCRAFT CO (US) 1985-01-02 EP disclosed
WO-1984002524-A1 2,2,2-TRIHALO-1-(TRIHALOMETHYL)ETHYLIDENE-BISBENZENETHIOLS HUGHES AIRCRAFT CO (US) 1984-07-05 WO disclosed