Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15584406 | 0.77 | GAA (0.46) | EPHX1GAALMNAKDM4EPOLB | |
| SCHEMBL23976387 | 0.77 | GAA (0.46) | EPHX1GAALMNAKDM4EPOLB | |
| SCHEMBL23976243 | 0.77 | GAA (0.46) | EPHX1GAALMNAKDM4EPOLB | |
| SCHEMBL8994031 | 0.77 | ALDH1A1 (0.40) | GAALMNACTSSCTSK | |
| SCHEMBL357909 | 0.77 | AAK1 (0.33) | GAAHDAC1HDAC6 | |
| SCHEMBL342692 | 0.77 | AAK1 (0.33) | GAAHDAC1HDAC6 | |
| SCHEMBL342693 | 0.77 | AAK1 (0.33) | GAAHDAC1HDAC6 | |
| SCHEMBL1706279 | 0.74 | CTSS (0.35) | EPHX1GAAHDAC4HDAC1HDAC6 | |
| SCHEMBL1054144 | 0.74 | CTSS (0.35) | EPHX1GAAHDAC4HDAC1HDAC6 | |
| SCHEMBL1054147 | 0.74 | CTSS (0.35) | EPHX1GAAHDAC4HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040706-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8609845-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2013-12-17 | — | — | US | disclosed |
| EP-1836201-B2 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH INC (US) | 2013-09-04 | — | — | EP | disclosed |
| EP-2240506-B1 | INHIBITORS OF IAP | GENENTECH INC (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20120270886-A1 | INHIBITORS OF IAP | KOEHLER MICHAEL F T (US) | 2012-10-25 | — | — | US | disclosed |
| US-8247557-B2 | IAP inhibitors | GENENTECH, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-8063218-B2 | Imidazopyridine inhibitors of IAP | GENENTECH, INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20090221630-A1 | IAP INHIBITORS | GENENTECH, INC. | 2009-09-03 | — | — | US | disclosed |
| WO-2009089502-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2009-07-16 | — | — | WO | disclosed |
| US-20090176822-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2009-07-09 | — | — | US | disclosed |
| WO-2008134679-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| EP-1973899-A2 | INHIBITORS OF IAP | Genentech, Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2008079735-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| EP-1836201-A1 | PYRROLIDINE INHIBITORS OF IAP | Genentech, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2007106192-A2 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2007-09-20 | — | — | WO | disclosed |
| US-20060167066-A1 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2006-07-27 | — | — | US | disclosed |
| WO-2006069063-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221630-A1 | IAP INHIBITORS | XIAP, BIRC5, BIRC3 | EPHX1 2917/4885GAA 1277/4885LMNA 1324/4885 |
| US-20090176822-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | EPHX1 3198/4885GAA 1437/4885LMNA 2663/4885 |
| US-20120270886-A1 | INHIBITORS OF IAP | XIAP, BIRC5, BIRC3 | EPHX1 2880/4885GAA 1363/4885LMNA 1317/4885 |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC3 | EPHX1 2948/4885GAA 1729/4885LMNA 1793/4885 |
| US-20060167066-A1 | Pyrrolidine inhibitors of IAP | BIRC5, XIAP, BIRC2 | EPHX1 3253/4885GAA 1448/4885LMNA 2675/4885 |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | BIRC5, XIAP, BIRC2 | EPHX1 3198/4885GAA 1437/4885LMNA 2663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.