Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 9/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 9/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 6/20 | 0.55 |
| ▸ | CDK1 | P06493 | 6/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 6/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 6/20 | 0.55 |
| ▸ | CDK4 | P11802 | 3/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.55 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.49 |
| ▸ | RAF1 | P04049 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.49 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Spongiacidin A SCHEMBL23938900 | 0.72 | CDK5 (0.56) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL3426241 | 0.70 | CCNB2 (0.54) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL7845370 | 0.70 | CDK5 (0.55) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL15426067 | 0.70 | CDK5 (0.73) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL3001277 | 0.68 | MAPT (0.52) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL13341120 | 0.68 | CDK5 (0.67) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL3424813 | 0.68 | CDK5 (0.67) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL3424811 | 0.68 | CDK5 (0.67) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL3427648 | 0.67 | TUBB4A (0.68) | CHEK1MAP2K1RAF1MAPK1TUBB4A | |
| SCHEMBL7837428 | 0.66 | MAP2K1 (1.00) | CDK5CDK5R1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7713958-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2010-05-11 | — | — | US | disclosed |
| US-20090137555-A1 | Compounds and Compositions as Protein Kinase Inhibitors | IRM LLC (BM) | 2009-05-28 | — | — | US | disclosed |
| US-7423031-B2 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2008-09-09 | — | — | US | disclosed |
| US-20050153955-A1 | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2005-07-14 | — | — | US | disclosed |
| WO-2004098520-A2 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153955-A1 | Compounds and compositions as protein kinase inhibitors | CDK1, CDK3, CDK11A | CDK5 16/4885CDK5R1 38/4885CCNB2 59/4885 |
| US-20090137555-A1 | Compounds and Compositions as Protein Kinase Inhibitors | CDK1, CDK3, CDK2 | CDK5 14/4885CDK5R1 37/4885CCNB2 78/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.