Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL623010 | 0.86 | PIK3CA (0.50) | PIK3CAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3403823 | 0.81 | PIK3CA (0.80) | PIK3CAGAAKDM4EALDH1A1PIK3R1 | |
| SCHEMBL1552351 | 0.81 | PIK3CA (0.55) | PIK3CAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL3130106 | 0.79 | PIK3CA (0.48) | PIK3CAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL3247973 | 0.79 | PIK3CA (0.47) | PIK3CAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL10298274 | 0.78 | ALDH1A1 (0.50) | PIK3CAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL3403839 | 0.77 | PIK3CA (0.51) | PIK3CAGAAKDM4EALDH1A1HPGD | |
| SCHEMBL8006407 | 0.77 | PIK3CA (0.82) | PIK3CAPIK3R1PIK3CDPIK3CBGRIA2 | |
| SCHEMBL3400775 | 0.77 | PIK3CA (0.77) | PIK3CAALDH1A1MAPTNPSR1PIK3R1 | |
| SCHEMBL7996628 | 0.76 | PIK3CA (0.80) | PIK3CAKDM4EALDH1A1PIK3R1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250160-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | Millennium Pharmaceuticals, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009094224-A1 | THIOPHENES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-07-30 | — | — | WO | disclosed |