Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264448 | 0.87 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBALDH1A1POLB | |
| SCHEMBL3425682 | 0.79 | PIK3CA (0.61) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 | |
| SCHEMBL3130106 | 0.75 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 | |
| SCHEMBL10288854 | 0.69 | PIK3CA (0.44) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 | |
| SCHEMBL3119056 | 0.69 | PIK3CA (0.41) | PIK3CAPIK3CDPIK3CBALDH1A1POLB | |
| SCHEMBL28725552 | 0.69 | IKBKB (0.43) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 | |
| SCHEMBL3126013 | 0.69 | IKBKB (0.52) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 | |
| SCHEMBL3387296 | 0.69 | PIK3CA (0.48) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 | |
| SCHEMBL3268335 | 0.69 | PIK3CA (0.42) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 | |
| Hydrochloric Acid SCHEMBL5010640 | 0.68 | PIK3CD (0.74) | PIK3CAPIK3CDPIK3CBIKBKBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001126-A1 | THIOPHENE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-01-07 | — | — | WO | disclosed |