Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 11/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003257 | 0.74 | HTR2C (0.40) | MEN1CYP3A4HTR2AMAPK1KMT2A | |
| SCHEMBL2817043 | 0.71 | CYP19A1 (0.47) | CYP17A1CYP19A1 | |
| SCHEMBL10389798 | 0.67 | GAA (0.37) | KDM4EMEN1ALDH1A1CYP3A4KMT2A | |
| SCHEMBL3427524 | 0.67 | ADRA2A (0.36) | MEN1CYP3A4MAPK1ADRA1AKMT2A | |
| SCHEMBL3427522 | 0.67 | CYP19A1 (0.55) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL2995990 | 0.65 | HTR2C (0.36) | HTR2AOPRK1 | |
| SCHEMBL24749387 | 0.62 | CYP19A1 (0.62) | CYP17A1CYP19A1CYP26A1KDM4ECYP11B1 | |
| SCHEMBL2139658 | 0.62 | ALDH1A1 (0.46) | ALDH1A1MAPTHTR2ANPSR1 | |
| SCHEMBL30027759 | 0.62 | ALDH1A1 (0.46) | ALDH1A1MAPTHTR2ANPSR1 | |
| SCHEMBL29415514 | 0.62 | ALDH1A1 (0.46) | ALDH1A1MAPTHTR2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213668-A2 | Imidazoles as aldosterone synthase inhibitors | Novartis AG (CH) | 2010-08-04 | — | — | EP | disclosed |