SCHEMBL2139658

SCHEMBL2139658

CC1CC(C)(C)c2ccccc21

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.46
MAPT P10636 2/20 0.46
HTR2C P28335 1/20 0.39
GAA P10253 2/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
CHRNA7 P36544 1/20 0.39
NOTUM Q6P988 1/20 0.39
HTR2A P28223 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29415514 1.00 ALDH1A1 (0.46) ALDH1A1MAPTHTR2CGAASMN1; SMN2
SCHEMBL30027759 1.00 ALDH1A1 (0.46) ALDH1A1MAPTHTR2CGAASMN1; SMN2
SCHEMBL3842197 0.79 HTR2C (0.37) ALDH1A1MAPTHTR2CGAASMN1; SMN2
SCHEMBL10603757 0.79 OPRM1 (0.43) ALDH1A1MAPTGAASMN1; SMN2HTR2A
SCHEMBL23505845 0.77 HTR2C (0.38) HTR2CNOTUMHTR2A
SCHEMBL14101425 0.77 PGR (0.44) ALDH1A1MAPTHTR2CGAASMN1; SMN2
SCHEMBL1508195 0.77 PGR (0.44) ALDH1A1MAPTHTR2CGAASMN1; SMN2
SCHEMBL192411 0.77 HTR2A (0.41) HTR2CHTR2A
SCHEMBL193611 0.77 HTR2A (0.41) HTR2CHTR2A
SCHEMBL29809193 0.77 HTR2A (0.41) HTR2CHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107418144-B Resin composition 味之素株式会社 2022-06-03 CN claimed
US-20200075862-A1 INDANE DERIVATIVES AND THEIR USE IN ORGANIC ELECTRONICS DOTTIKON ES HOLDING AG (CH) 2020-03-05 US claimed
CN-110740986-A Indane derivatives and their use in organic electronic devices 多蒂肯独家合成控股公司 2020-01-31 CN claimed
CN-106748963-B Polyamide-imides and preparation method thereof containing indane structural 北京航空航天大学 2019-08-02 CN claimed
CN-107418144-A Resin combination 味之素株式会社 2017-12-01 CN claimed
US-20110065962-A1 PROCESS FOR THE PREPARATION OF AROMATIC ALPHA-HYDROXY KETONES MENEGUZZO ENZO 2011-03-17 US claimed
JP-56020524-A None JP disclosed
EP-4463504-A1 CAPPED POLY(PHENYLENE ETHER) AND CURABLE THERMOSETTING COMPOSITION COMPRISING THE SAME SHPP Global Technologies B.V. (NL) 2024-11-20 EP disclosed
US-12129429-B1 Method for paraffin inhibiting Skaiblue Fund LLC 2024-10-29 US disclosed
US-11787942-B2 Polyimide precursor solution, method for producing porous polyimide film, porous polyimide film, and insulated wire FUJIFILM BUSINESS INNOVATION CORP. (JP) 2023-10-17 US disclosed
US-20230322830-A1 Novel ruthenium complexes, methods of their preparation and application thereof in olefin cross metathesis APEIRON SYNTHESIS S.A. (PL) 2023-10-12 US disclosed
EP-3621946-B1 INDANE DERIVATIVES AND THEIR USE IN ORGANIC ELECTRONICS DOTTIKON ES HOLDING AG (CH) 2023-09-06 EP disclosed
WO-2023135460-A1 CAPPED POLY(PHENYLENE ETHER) AND CURABLE THERMOSETTING COMPOSITION COMPRISING THE SAME SHPP GLOBAL TECHNOLOGIES B.V. (NL) 2023-07-20 WO disclosed
EP-0322245-A2 Process for preparation of resorcinol INDSPEC CHEMICAL CORPORATION (US) 1989-06-28 EP disclosed
EP-0231953-A2 Light-absorbing resins for display device, display devices using the resin and method of manufacturing the same KABUSHIKI KAISHA TOSHIBA (JP) 1987-08-12 EP disclosed
US-4620056-A ALKYLATION OF SUBSTITUTED AROMATIC HYDROCARBON WITH OLEFINS IN THE PRESENCE OF SODIUM AND A POTASSIUM COMPOUND NIPPON PETROCHEMICALS CO., LTD. (JP) 1986-10-28 US disclosed
EP-0188337-A2 Thermosettable heat-resistant epoxy resin composition SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1986-07-23 EP disclosed
EP-0173335-A2 Method for producing aromatic hydrocarbons NIPPON PETROCHEMICALS COMPANY, LIMITED (JP) 1986-03-05 EP disclosed
JP-S5620524-A PREPARATION OF 1,1,3-TRIMETHYL-5-ISOPROPYL-2-INDENE MITSUI PETROCHEM IND LTD 1981-02-26 JP disclosed
US-4123469-A Process for production of bicyclic compounds INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) 1978-10-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110065962-A1 PROCESS FOR THE PREPARATION OF AROMATIC ALPHA-HYDROXY KETONES KHK, BCKDK, PAH ALDH1A1 370/4885MAPT 2526/4885HTR2C 1956/4885
US-20230322830-A1 Novel ruthenium complexes, methods of their preparation and application thereof in olefin cross metathesis CYP4F11, CYP4F3, CYP4F12 ALDH1A1 1063/4885MAPT 4158/4885HTR2C 2648/4885
US-20200075862-A1 INDANE DERIVATIVES AND THEIR USE IN ORGANIC ELECTRONICS KCNJ2, KCNA2, CYP2J2 ALDH1A1 1964/4885MAPT 3034/4885HTR2C 218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.