Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.49 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | OXTR | P30559 | 4/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630630 | 0.97 | CRHBP (0.47) | CRHBPCRHR2MAPTTP53OXTR | |
| SCHEMBL1629094 | 0.94 | CRHBP (0.52) | CRHBPCRHR2MAPTTP53OXTR | |
| SCHEMBL3425877 | 0.92 | CRHBP (0.49) | CRHBPCRHR2MAPTTP53OXTR | |
| SCHEMBL1632105 | 0.91 | CRHBP (0.56) | CRHBPCRHR2MAPTTP53OXTR | |
| SCHEMBL1629052 | 0.90 | HTT (0.49) | CRHBPCRHR2MAPTTP53OXTR | |
| SCHEMBL1630069 | 0.90 | KMT2A (0.54) | CRHBPCRHR2MAPTOXTRAVPR1A | |
| SCHEMBL1630032 | 0.90 | KEAP1 (0.51) | MAPTOXTRAVPR1ANPSR1PKM | |
| SCHEMBL1629490 | 0.90 | KEAP1 (0.51) | MAPTOXTRAVPR1ANPSR1PKM | |
| SCHEMBL3423315 | 0.90 | KEAP1 (0.51) | MAPTOXTRAVPR1ANPSR1PKM | |
| SCHEMBL1630672 | 0.89 | ALDH1A1 (0.48) | CRHBPCRHR2MAPTOXTRAVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245006-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009092642-A1 | SULFONAMIDES AS OREXIN ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-07-30 | — | — | WO | disclosed |