Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL343443 | 0.98 | ALDH1A1 (0.69) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL28934013 | 0.88 | ALDH1A1 (0.65) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL9871595 | 0.86 | ALDH1A1 (0.62) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL3543222 | 0.85 | LMNA (0.53) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL3543227 | 0.85 | LMNA (0.53) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL8506264 | 0.83 | TSHR (0.54) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL16594784 | 0.82 | TDP1 (0.65) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL17459104 | 0.82 | ALDH1A1 (0.67) | ALDH1A1LMNASMN1; SMN2TSHRNAAA | |
| SCHEMBL8454471 | 0.81 | ALDH1A1 (0.71) | ALDH1A1LMNASMN1; SMN2TSHRTDP1 | |
| SCHEMBL3845851 | 0.81 | ALDH1A1 (0.64) | ALDH1A1LMNASMN1; SMN2TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46234-E1 | Tissue adhesive and sealant comprising polyglycerol aldehyde | ACTAMAX SURGICAL MATERIALS, LLC (US) | 2016-12-13 | — | — | US | disclosed |
| EP-2411062-B1 | TISSUE ADHESIVE AND SEALANT COMPRISING POLYGLYCEROL ALDEHYDE | ACTAMAX SURGICAL MATERIALS LLC (US) | 2014-08-20 | — | — | EP | disclosed |
| US-8680200-B2 | Polyglycerol aldehydes | ACTAMAX SURGICAL MATERIALS LLC (US) | 2014-03-25 | — | — | US | disclosed |
| US-8404779-B2 | Tissue adhesive and sealant comprising polyglycerol aldehyde | ACTAMAX SURGICAL MATERIALS LLC (US) | 2013-03-26 | — | — | US | disclosed |
| EP-2411448-B1 | POLYGLYCEROL ALDEHYDES | ACTAMAX SURGICAL MATERIALS LLC (US) | 2013-03-20 | — | — | EP | disclosed |
| US-20120029149-A1 | POLYGLYCEROL ALDEHYDES | ACTAMAX SURGICAL MATERIALS, LLC (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2411448-A1 | POLYGLYCEROL ALDEHYDES | Actamax Surgical Materials LLC (US) | 2012-02-01 | — | — | EP | disclosed |
| EP-2411062-A1 | TISSUE ADHESIVE AND SEALANT COMPRISING POLYGLYCEROL ALDEHYDE | Actamax Surgical Materials LLC (US) | 2012-02-01 | — | — | EP | disclosed |
| US-20120014909-A1 | TISSUE ADHESIVE AND SEALANT COMPRISING POLYGLYCEROL ALDEHYDE | ACTAMAX SURGICAL MATERIALS, LLC (US) | 2012-01-19 | — | — | US | disclosed |
| WO-2010111570-A1 | POLYGLYCEROL ALDEHYDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111594-A1 | TISSUE ADHESIVE AND SEALANT COMPRISING POLYGLYCEROL ALDEHYDE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120029149-A1 | POLYGLYCEROL ALDEHYDES | GGH, TGM3, FABP2 | ALDH1A1 75/4885LMNA 2994/4885SMN1; SMN2 2320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.