Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | XDH | P47989 | 2/20 | 0.33 |
| ▸ | PI4KA | P42356 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.33 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12344590 | 0.74 | PIK3C3 (0.37) | PIK3C3PIK3CAAKT1CHEK1DYRK1A | |
| SCHEMBL10329 | 0.73 | DYRK1A (0.50) | PIK3C3CHEK1DYRK1ARETMAPK1 | |
| SCHEMBL14977221 | 0.73 | NAMPT (0.40) | PIK3C3PIK3CAAKT1CHEK1MAPK1 | |
| SCHEMBL2619214 | 0.73 | CCR1 (0.46) | PIK3C3PIK3CAAKT1CHEK1PDPK1 | |
| SCHEMBL11982852 | 0.73 | PIK3C3 (0.36) | PIK3C3PIK3CAAKT1CHEK1DYRK1A | |
| SCHEMBL29705375 | 0.73 | FGFR1 (0.40) | PIK3C3PIK3CAAKT1CHEK1DYRK1A | |
| SCHEMBL9940746 | 0.73 | NOS1 (0.55) | PIK3CACHEK1DYRK1ARETMAPK1 | |
| SCHEMBL15243458 | 0.73 | NOS1 (0.50) | PIK3C3PIK3CAAKT1CHEK1DYRK1A | |
| SCHEMBL29705478 | 0.73 | MAPT (0.50) | PIK3C3PIK3CAAKT1CHEK1DYRK1A | |
| SCHEMBL20095380 | 0.70 | BRAF (0.40) | PIK3C3PIK3CAAKT1ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265610-A1 | PYRAZOLE [3, 4-B]PYRIDINE RAF INHIBITORS | Array Biopharma, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009111279-A1 | PYRAZOLE [3, 4-B] PYRIDINE RAF INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-09-11 | — | — | WO | disclosed |