Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15077043 | 0.79 | PDE4A (0.42) | PDE4A | |
| SCHEMBL17972910 | 0.78 | CARM1 (0.43) | PDE4A | |
| SCHEMBL22426537 | 0.78 | CARM1 (0.43) | PDE4A | |
| SCHEMBL9729192 | 0.77 | KMT2A (0.53) | PTGS1PTGS2CXCL8 | |
| SCHEMBL4554195 | 0.77 | KMT2A (0.53) | PTGS1PTGS2CXCL8 | |
| SCHEMBL7330787 | 0.74 | IRAK4 (0.59) | CXCL8PARP10 | |
| SCHEMBL23057958 | 0.74 | KDM4E (0.48) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL28968076 | 0.73 | CYP19A1 (0.56) | CYP19A1 | |
| SCHEMBL7163802 | 0.73 | KCNH2 (0.56) | PDE4APDE4BPDE4DPDE4CKAT2B | |
| SCHEMBL9321170 | 0.73 | CXCL8 (0.54) | PTGS1PTGS2CXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254879-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | Glenmark Pharmaceuticals S.A. (CH) | 2010-12-01 | — | — | EP | claimed |
| WO-2009084034-A2 | CHROMANE DERIVATIVES AS TRPV3 MODULATORS | GLENMARK PHARMACEUTICALS, S. A. (CH) | 2009-07-09 | — | — | WO | claimed |