Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | MAP2 | P11137 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554195 | 0.85 | KMT2A (0.53) | IRAK4ACHECXCL8KMT2AKDM4E | |
| SCHEMBL9729192 | 0.85 | KMT2A (0.53) | IRAK4ACHECXCL8KMT2AKDM4E | |
| SCHEMBL9321170 | 0.80 | CXCL8 (0.54) | IRAK4CXCL8KMT2ALMNATDP1 | |
| SCHEMBL1685873 | 0.79 | CTNNB1 (0.53) | CXCL8LMNAPARP10HTT | |
| SCHEMBL25245395 | 0.77 | IRAK4 (0.53) | IRAK4ALDH1A1ACHEKMT2ASLC9A1 | |
| SCHEMBL8317971 | 0.76 | LIPE (0.51) | ALDH1A1KDM4ETDP1HTT | |
| SCHEMBL8053594 | 0.75 | IRAK4 (0.48) | IRAK4ALDH1A1ACHEKMT2AKDM4E | |
| SCHEMBL6055378 | 0.75 | ALDH1A1 (0.50) | IRAK4ALDH1A1ACHEKMT2AKDM4E | |
| SCHEMBL30387546 | 0.74 | CXCL8 (0.42) | IRAK4CXCL8KMT2AHTT | |
| SCHEMBL1827130 | 0.74 | MAPT (0.47) | ALDH1A1CXCL8KMT2AKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0852142-A1 | Diamines in the treatment of arrhythmia | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1998-07-08 | — | — | EP | disclosed |
| EP-0639973-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1995-03-01 | — | — | EP | disclosed |
| WO-1993023024-A1 | DIAMINES IN THE TREATMENT OF ARRHYTHMIA | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1993-11-25 | — | — | WO | disclosed |