Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | UBE2M | P61081 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | NMBR | P28336 | 2/20 | 0.39 |
| ▸ | GRPR | P30550 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404762 | 0.78 | NMBR (0.49) | SMN1; SMN2SOAT2SOAT1NMBR | |
| SCHEMBL3409925 | 0.75 | KMT2A (0.36) | SMN1; SMN2UBE2MDCUN1D1LMNAKMT2A | |
| SCHEMBL6803628 | 0.70 | UBE2M (0.47) | SMN1; SMN2UBE2MDCUN1D1LMNAKMT2A | |
| SCHEMBL9273516 | 0.69 | UBE2M (0.65) | UBE2MDCUN1D1 | |
| SCHEMBL9273683 | 0.69 | UBE2M (0.65) | UBE2MDCUN1D1 | |
| SCHEMBL9273510 | 0.69 | UBE2M (0.65) | UBE2MDCUN1D1 | |
| SCHEMBL855625 | 0.69 | SOAT2 (0.52) | SMN1; SMN2UBE2MDCUN1D1LMNAKMT2A | |
| SCHEMBL9275119 | 0.69 | UBE2M (0.52) | UBE2MDCUN1D1LMNAKMT2ASOAT2 | |
| SCHEMBL9275114 | 0.69 | UBE2M (0.52) | UBE2MDCUN1D1LMNAKMT2ASOAT2 | |
| SCHEMBL6802084 | 0.68 | UBE2M (0.45) | UBE2MDCUN1D1KMT2ASOAT2SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200979-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009030752-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-12 | — | — | WO | disclosed |