Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NMBR | P28336 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.34 |
| ▸ | HTR1E | P28566 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | GRPR | P30550 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414059 | 0.76 | NMBR (0.47) | KMT2ALMNANMBRALDH1A1CYP3A4 | |
| SCHEMBL3430783 | 0.75 | SMN1; SMN2 (0.45) | KMT2ALMNANMBRSMN1; SMN2UBE2M | |
| SCHEMBL3414001 | 0.75 | NMBR (0.45) | KMT2ALMNANMBRMEN1ALDH1A1 | |
| SCHEMBL3409923 | 0.73 | SOAT2 (0.39) | KMT2ALMNAMEN1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3410912 | 0.67 | NLRP3 (0.43) | KMT2ALMNANLRP3 | |
| SCHEMBL3412557 | 0.66 | NLRP3 (0.46) | KMT2ANMBRMEN1NLRP3TDP1 | |
| SCHEMBL3414079 | 0.66 | NMBR (0.49) | KMT2ALMNANMBRMEN1ALDH1A1 | |
| SCHEMBL3409553 | 0.66 | ALDH1A1 (0.47) | KMT2ANMBRMEN1ALDH1A1CYP3A4 | |
| SCHEMBL3407725 | 0.64 | ALDH1A1 (0.48) | KMT2ALMNANMBRALDH1A1CYP3A4 | |
| SCHEMBL3405365 | 0.64 | PKM (0.36) | LMNATP53GAANMBRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200979-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2010-06-30 | — | — | EP | disclosed |
| WO-2009030752-A1 | NOVEL DERIVATIVES OF PHENYLUREAS, INHIBITORS OF THE SOAT-1 ENZYME, PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-12 | — | — | WO | disclosed |