Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ICMT | O60725 | 15/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.43 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13760426 | 1.00 | MAPT (0.54) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL12793306 | 1.00 | MAPT (0.54) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL13760403 | 1.00 | MAPT (0.54) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL12793308 | 0.93 | ALDH1A1 (0.47) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL6522976 | 0.91 | MAPT (0.45) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL6524261 | 0.89 | MAPT (0.44) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL12847996 | 0.89 | ITGB1 (0.43) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL12848183 | 0.89 | ITGB1 (0.43) | MAPTALDH1A1ICMTITGB1ITGA4 | |
| SCHEMBL6524871 | 0.88 | MAPT (0.57) | MAPTALDH1A1ICMTMEN1TRPA1 | |
| SCHEMBL12793069 | 0.88 | MAPT (0.57) | MAPTALDH1A1ICMTMEN1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110053901-A1 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | SIGNUM BIOSCIENCES, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053901-A1 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | SIGNUM BIOSCIENCES, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| EP-2252277-A2 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | Signum Biosciences, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009102997-A2 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | SIGNUM BIOSCIENCES, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053901-A1 | ACETYL MIMIC COMPOUNDS FOR THE INHIBITION OF ISOPRENYL-S-CYSTEINYL METHYLTRANSFERASE | MPO, CYSLTR1, HNMT | MAPT 1682/4885ALDH1A1 2137/4885ICMT 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.