Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 6/20 | 0.47 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | MARS1 | P56192 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428213 | 0.90 | MEN1 (0.51) | RPA1PPP1CAMEN1KMT2AATM | |
| SCHEMBL3427858 | 0.90 | PPP1CA (0.48) | RPA1PPP1CAMEN1KMT2AATM | |
| SCHEMBL3430065 | 0.88 | RPA1 (0.44) | RPA1KMT2APTGS2 | |
| SCHEMBL3430105 | 0.86 | KMT2A (0.54) | RPA1PPP1CAMEN1KMT2AATM | |
| SCHEMBL14995442 | 0.86 | RPA1 (0.40) | RPA1PPP1CAMEN1KMT2AATM | |
| SCHEMBL3429253 | 0.86 | RPA1 (0.42) | RPA1PPP1CAMEN1KMT2AATM | |
| SCHEMBL3427714 | 0.86 | RPA1 (0.43) | RPA1PPP1CAMEN1KMT2AATM | |
| SCHEMBL3427610 | 0.86 | RPA1 (0.45) | RPA1PTGS2ALDH1A1KDRRXFP1 | |
| SCHEMBL3425400 | 0.86 | SLC5A1 (0.46) | RPA1MARS1 | |
| SCHEMBL3434938 | 0.85 | RPA1 (0.45) | RPA1PPP1CAMEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254885-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AiCuris GmbH & Co. KG (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009115213-A1 | (PYRAZOLYL CARBONYL)IMIDAZOLIDINONE DERIVATIVES FOR THE TREATMENT OF RETROVIRAL DISEASES | AICURIS GMBH & CO. KG (DE) | 2009-09-24 | — | — | WO | disclosed |