Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14231089 | 0.95 | RAB9A (0.47) | HPGDRAB9APOLBMAPTKMT2A | |
| SCHEMBL29150562 | 0.74 | HPGD (0.59) | HPGDRAB9APOLBMAPTKMT2A | |
| SCHEMBL28018180 | 0.74 | ALDH1A1 (0.46) | HPGDRAB9APOLBMAPTKMT2A | |
| SCHEMBL13313010 | 0.73 | SMN1; SMN2 (0.57) | HPGDRAB9APOLBMAPTKMT2A | |
| SCHEMBL5163554 | 0.73 | P2RX7 (0.47) | POLBKMT2AMEN1SMN1; SMN2NPC1 | |
| SCHEMBL3431267 | 0.72 | ALDH1A1 (0.41) | HPGDRAB9APOLBMAPTKMT2A | |
| SCHEMBL3164153 | 0.72 | RAB9A (0.50) | HPGDRAB9APOLBMAPTKMT2A | |
| SCHEMBL19128428 | 0.72 | ALDH1A1 (0.63) | HPGDRAB9APOLBMAPTKMT2A | |
| SCHEMBL5163142 | 0.72 | P2RX7 (0.49) | HPGDSMN1; SMN2GAANPC1 | |
| SCHEMBL25147377 | 0.71 | BCHE (0.62) | HPGDRAB9AKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252616-A1 | PYRAZOLOPYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009097446-A1 | PYRAZOLOPYRIMIDINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-08-06 | — | — | WO | disclosed |