Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSC | P53634 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL8981660 | 1.00 | DPP4 (0.41) | DPP4DPP7DPP8DPP9ALPI | |
| Phenylalanine SCHEMBL18957689 | 0.96 | ALPI (0.44) | DPP4DPP7DPP8DPP9ALPI | |
| 4-Nitroaniline SCHEMBL16269538 | 0.89 | SLC6A3 (0.40) | DPP4DPP7DPP8DPP9PKM | |
| 4-Nitroaniline SCHEMBL6600220 | 0.89 | ALDH1A1 (0.42) | DPP4DPP7DPP8DPP9PKM | |
| Phenylalanine SCHEMBL1094608 | 0.87 | SLC7A5 (0.54) | DPP4DPP7DPP8DPP9ALPI | |
| Phenylalanine SCHEMBL3062589 | 0.87 | SLC7A5 (0.54) | DPP4DPP7DPP8DPP9ALPI | |
| Dl-Phenylalanine SCHEMBL21899689 | 0.87 | SLC7A5 (0.54) | DPP4DPP7DPP8DPP9ALPI | |
| Dl-Phenylalanine SCHEMBL21899690 | 0.87 | SLC7A5 (0.54) | DPP4DPP7DPP8DPP9ALPI | |
| Dl-Phenylalanine SCHEMBL27867001 | 0.87 | SLC7A5 (0.54) | DPP4DPP7DPP8DPP9ALPI | |
| Dl-Phenylalanine SCHEMBL29006920 | 0.85 | CTSC (0.45) | DPP4DPP7DPP8DPP9ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3310911-A1 | BACILLUS GIBSONII-CLADE SERINE PROTEASES | Danisco US Inc. (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2016205755-A1 | BACILLUS GIBSONII-CLADE SERINE PROTEASES | DANISCO US INC. (US) | 2016-12-22 | — | — | WO | disclosed |
| EP-2252682-A1 | CLEANING COMPOSITIONS | The Procter & Gamble Company (US) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009102854-A1 | CLEANING COMPOSITIONS | THE PROCTER & GAMBLE COMPANY (US) | 2009-08-20 | — | — | WO | disclosed |