Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | RUNX1 | Q01196 | 2/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.41 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377915 | 0.79 | CYP1A2 (0.45) | SMN1; SMN2ALDH1A1HPGDHSD17B10HDAC6 | |
| SCHEMBL3476576 | 0.77 | TRPV1 (0.50) | TRPV1RUNX1CBFBCACNA1BCHEK2 | |
| SCHEMBL3474853 | 0.76 | PDE4A (0.43) | KDM4EALDH1A1HPGDHSD17B10POLB | |
| Hydrochloric Acid SCHEMBL11903522 | 0.74 | PDE10A (0.67) | HTTNPC1RAB9ASMN1; SMN2TRPV1 | |
| SCHEMBL3430623 | 0.73 | FFAR1 (0.43) | HTTKDM4EALDH1A1GAAHPGD | |
| SCHEMBL3431393 | 0.72 | SERPINE1 (0.43) | HDAC6SERPINE1 | |
| Hydrochloric Acid SCHEMBL11903596 | 0.69 | GAA (0.61) | TRPV1KDM4EGAAPDE10ARUNX1 | |
| Hydrochloric Acid SCHEMBL11903518 | 0.67 | RAB9A (0.56) | HTTNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5952465 | 0.67 | RUNX1 (0.49) | TRPV1PDE10ARUNX1CBFBCHEK2 | |
| SCHEMBL11903481 | 0.67 | TRPV1 (0.72) | HTTNPC1RAB9ASMN1; SMN2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053757-A1 | 2 -OXOQUINOXALIN BLOCKERS OF THE LATE SODIUM CHANNEL | GILEAD PALO ALTO, INC. (US) | 2010-05-14 | — | — | WO | claimed |