Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411255 | 0.79 | DYRK1A (0.40) | S1PR3METNQO2MAOBDYRK1A | |
| Bromoethane SCHEMBL3414106 | 0.73 | DYRK1A (0.35) | S1PR3METNQO2DYRK1AKEAP1 | |
| SCHEMBL3413945 | 0.71 | KEAP1 (0.46) | METDYRK1AKEAP1DAOCPB2 | |
| SCHEMBL3414108 | 0.71 | DYRK1A (0.34) | S1PR3METNQO2DYRK1AKEAP1 | |
| SCHEMBL3431615 | 0.70 | FYN (0.53) | METNQO2DYRK1A | |
| SCHEMBL3636986 | 0.67 | CPB2 (0.45) | S1PR3MAOBDYRK1AKEAP1DAO | |
| SCHEMBL12489426 | 0.66 | DYRK1A (0.46) | S1PR3METNQO2MAOBDYRK1A | |
| SCHEMBL24087284 | 0.66 | DYRK1A (0.49) | S1PR3METNQO2DYRK1AKEAP1 | |
| SCHEMBL13692842 | 0.65 | MET (0.35) | METNQO2 | |
| SCHEMBL3409818 | 0.64 | DYRK1A (0.37) | S1PR3METNQO2DYRK1AKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265614-A1 | IMIDAZO [1,2-B]PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE | Novartis AG (CH) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009106577-A1 | IMIDAZO [1,2-B] PYRIDAZINE DERIVATIVES FOR THE TREATMENT OF C-MET TYROSINE KINASE MEDIATED DISEASE | NOVARTIS AG (CH) | 2009-09-03 | — | — | WO | disclosed |