Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.32 |
| ▸ | G6PD | P11413 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 2/20 | 0.30 |
| ▸ | DRD4 | P21917 | 2/20 | 0.30 |
| ▸ | DRD3 | P35462 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916585 | 0.83 | — | — | |
| SCHEMBL916719 | 0.81 | POLB (0.36) | — | |
| SCHEMBL3923615 | 0.80 | PAK1 (0.40) | — | |
| SCHEMBL915798 | 0.78 | DRD2 (0.36) | DRD2DRD4DRD3 | |
| SCHEMBL3932218 | 0.77 | DKK1 (0.36) | DRD2DRD4DRD3 | |
| SCHEMBL3928070 | 0.77 | ROCK2 (0.37) | DRD2DRD4DRD3 | |
| SCHEMBL10292716 | 0.77 | IGF1R (0.44) | — | |
| SCHEMBL3923740 | 0.76 | SMO (0.40) | — | |
| SCHEMBL3926065 | 0.76 | PIK3CB (0.36) | — | |
| SCHEMBL1268788 | 0.74 | IGF1R (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262806-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009111531-A1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-11 | — | — | WO | disclosed |