Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR1D | P28221 | 2/20 | 0.50 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | AGXT | P21549 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.46 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.46 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6354859 | 0.98 | ADRA2C (0.54) | ADRA2CHTR2AHTR1DHTR1BAGXT | |
| SCHEMBL30900395 | 0.82 | ADRA2C (0.50) | ADRA2CHTR2AHTR1DHTR1BAGXT | |
| SCHEMBL2378486 | 0.81 | ADRA2C (0.61) | ADRA2CHTR2AHTR1DHTR1BAGXT | |
| SCHEMBL3314863 | 0.80 | NPC1 (0.55) | ADRA2CMAPTTSHRNPC1POLB | |
| SCHEMBL28000258 | 0.78 | HTR2A (0.64) | ADRA2CHTR2AHTR1DHTR1BHTR1A | |
| SCHEMBL30577378 | 0.78 | HTR1D (0.60) | HTR2AHTR1DHTR1BHTR1AHTR7 | |
| SCHEMBL25156906 | 0.77 | ADRA2C (0.56) | ADRA2CHTR2AHTR1DHTR1BAGXT | |
| SCHEMBL13994004 | 0.77 | ADRA2C (0.56) | ADRA2CHTR2AHTR1DHTR1BAGXT | |
| SCHEMBL13996557 | 0.77 | ADRA2C (0.56) | ADRA2CHTR2AHTR1DHTR1BAGXT | |
| SCHEMBL3966558 | 0.77 | ADRA2C (0.55) | ADRA2CHTR2AHTR1DHTR1BAGXT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231625-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | GlaxoSmithKline LLC (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009076140-A1 | THIAZOLE AND OXAZOLE KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-18 | — | — | WO | disclosed |
| EP-0712397-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-22 | — | — | EP | disclosed |
| WO-1995004729-A1 | AMIDE DERIVATIVES AS 5HT1D RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-02-16 | — | — | WO | disclosed |