Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | AGXT | P21549 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.43 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.43 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.43 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21966131 | 0.83 | LMNA (0.49) | AGXTCASP3CASP7PLOD2PLOD3 | |
| SCHEMBL21965859 | 0.83 | ADRB1 (0.57) | HTR2AHTR1AHTR2CHTR7DRD3 | |
| SCHEMBL2378486 | 0.81 | ADRA2C (0.61) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL22742655 | 0.81 | HTR3A (0.59) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL13996557 | 0.81 | ADRA2C (0.56) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL21965752 | 0.80 | ADRA2C (0.53) | ADRA2CKDM1AALDH1A1KDM4EGAA | |
| SCHEMBL22169759 | 0.78 | BRD4 (0.58) | ADRA2CHTR2AHTR1AHTR1DHTR1B | |
| SCHEMBL25156906 | 0.77 | ADRA2C (0.56) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL3433102 | 0.77 | ADRA2C (0.56) | ADRA2CHTR2AHTR1AHTR2CHTR7 | |
| SCHEMBL5543193 | 0.76 | ADRA2C (0.54) | ADRA2CHTR2AHTR1AHTR2CHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465726-B2 | Substituted pyrrolo[2.3-B]pyridines | OSI PHARMACEUTICALS, INC. (US) | 2008-12-16 | — | — | US | disclosed |