Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945731 | 1.00 | CNR2 (0.40) | CNR2PARGALDH1A1PDGFRBKDR | |
| SCHEMBL945617 | 0.80 | GPR84 (0.54) | PDGFRB | |
| SCHEMBL1855927 | 0.78 | NPC1 (0.57) | ALDH1A1PDGFRBMAPK1CDK2 | |
| SCHEMBL947139 | 0.78 | SLC6A4 (0.45) | CNR2PARGALDH1A1PDGFRBPIK3C2A | |
| SCHEMBL3433438 | 0.77 | CNR2 (0.45) | CNR2PARGCNR1CCNT1CCNA2 | |
| SCHEMBL3433442 | 0.77 | CNR2 (0.45) | CNR2PARGCNR1CCNT1CCNA2 | |
| SCHEMBL944734 | 0.77 | GPR84 (0.48) | ALDH1A1 | |
| SCHEMBL944759 | 0.76 | PIK3C2A (0.43) | CNR2ALDH1A1PDGFRBPIK3C2APIK3C2B | |
| SCHEMBL3434033 | 0.72 | HTR1A (0.37) | PARGALDH1A1PIK3C2APIK3C2B | |
| SCHEMBL3433906 | 0.72 | PIK3C2A (0.41) | ALDH1A1PIK3C2APIK3C2BMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170906-B1 | FUSED THIAZOLE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA SA (BE) | 2013-04-03 | — | — | EP | disclosed |
| WO-2010146351-A1 | INDOLYLMETHYL-MORPHOLINE DERIVATIVES AS KINASE INHIBITORS | UCB PHARMA S.A. (BE) | 2010-12-23 | — | — | WO | disclosed |