Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 9/20 | 0.37 |
| ▸ | PPARG | P37231 | 9/20 | 0.37 |
| ▸ | PPARD | Q03181 | 6/20 | 0.37 |
| ▸ | FPR2 | P25090 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433469 | 0.84 | PPARA (0.40) | PPARAPPARGPPARDEPHX2PSEN1 | |
| SCHEMBL3396254 | 0.82 | PTGDR2 (0.45) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL3433346 | 0.78 | PTGDR2 (0.45) | PPARAPPARGPPARDEPHX2PTGDR2 | |
| SCHEMBL151169 | 0.78 | PTGDR2 (0.49) | PTGDR2 | |
| SCHEMBL3426982 | 0.76 | PPARA (0.42) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL3433773 | 0.75 | PPARA (0.43) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL15021253 | 0.74 | ITGB1 (0.41) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL3397145 | 0.73 | PPARA (0.39) | PPARAPPARGPPARDPSEN1PSEN2 | |
| SCHEMBL136780 | 0.70 | PTGDR2 (0.57) | PTGDR2 | |
| SCHEMBL3411652 | 0.70 | PPID (0.38) | PPARAPPARGPPARDEPHX2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257524-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009099902-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |