Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 14/20 | 0.43 |
| ▸ | PPARD | Q03181 | 9/20 | 0.43 |
| ▸ | PPARG | P37231 | 5/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.43 |
| ▸ | RORC | P51449 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3433469 | 0.92 | PPARA (0.40) | PPARAPPARDPPARGPSEN1PSEN2 | |
| SCHEMBL3426982 | 0.90 | PPARA (0.42) | PPARAPPARDPPARGPSEN1PSEN2 | |
| SCHEMBL3396254 | 0.89 | PTGDR2 (0.45) | PPARAPPARDPPARGPSEN1PSEN2 | |
| SCHEMBL15021253 | 0.88 | ITGB1 (0.41) | PPARAPPARDPPARGPSEN1PSEN2 | |
| SCHEMBL139144 | 0.79 | PTGDR2 (0.51) | — | |
| SCHEMBL3433770 | 0.78 | PTGDR2 (0.54) | PPARAPPARDPPARGRORCLMNA | |
| SCHEMBL3433349 | 0.75 | PPARA (0.37) | PPARAPPARDPPARGPSEN1PSEN2 | |
| SCHEMBL139840 | 0.72 | PTGDR2 (0.42) | LMNA | |
| SCHEMBL136717 | 0.71 | PTGDR2 (0.54) | — | |
| SCHEMBL3428624 | 0.71 | CNR2 (0.38) | PPARAPPARDPPARGPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245002-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | Amira Pharmaceuticals, Inc. (US) | 2010-11-03 | — | — | EP | claimed |
| WO-2009099901-A1 | N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS | AMIRA PHARMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | claimed |