SCHEMBL3433476

SCHEMBL3433476

Cc1ccccc1-c1cn2cc(-c3ccc(CO)o3)ccc2n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 6/20 0.43
EPAS1 Q99814 6/20 0.43
ALDH1A1 P00352 4/20 0.42
KDM4E B2RXH2 3/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
ALDH1A3 P47895 2/20 0.42
SLC2A1 P11166 1/20 0.42
ADORA2A P29274 1/20 0.41
PDCD1 Q15116 1/20 0.41
CD274 Q9NZQ7 1/20 0.41
NR4A2 P43354 2/20 0.40
ALDH1A2 O94788 1/20 0.40
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
KMT2A Q03164 2/20 0.39
TP53 P04637 1/20 0.39
PKM P14618 1/20 0.39
HPGD P15428 1/20 0.39
TSHR P16473 1/20 0.39
CDK5 Q00535 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL217834 0.86 NR4A2 (0.45) HIF1AEPAS1ALDH1A1KDM4EALDH1A3
SCHEMBL219498 0.84 NPC1 (0.56) HIF1AEPAS1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL217845 0.84 ALDH1A3 (0.58) HIF1AEPAS1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL216917 0.81 ADORA2A (0.39) HIF1AEPAS1ALDH1A1ALDH1A3ADORA2A
SCHEMBL217541 0.81 ADORA2A (0.41) HIF1AEPAS1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL218465 0.80 RAB9A (0.40) HIF1AEPAS1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL218075 0.80 ALDH1A1 (0.43) HIF1AEPAS1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL216669 0.80 NR4A2 (0.49) ALDH1A1KDM4ESMN1; SMN2ALDH1A3SLC2A1
SCHEMBL216873 0.79 ADORA2A (0.70) HIF1AEPAS1ALDH1A1KDM4ESMN1; SMN2
SCHEMBL218434 0.79 CYP2A6 (0.44) HIF1AEPAS1ALDH1A1KDM4EALDH1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2262804-A1 POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-aventis (FR) 2010-12-22 EP claimed
WO-2009144392-A1 POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- Α] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2009-12-03 WO claimed
EP-2262804-A1 POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF Sanofi-aventis (FR) 2010-12-22 EP disclosed
WO-2009144392-A1 POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- Α] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2009-12-03 WO disclosed