Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 16/20 | 0.52 |
| ▸ | MTOR | P42345 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432395 | 0.81 | MAP3K12 (0.52) | MAP3K12 | |
| SCHEMBL21658972 | 0.80 | MAP3K12 (0.48) | MAP3K12MTORPIK3CA | |
| SCHEMBL3433510 | 0.78 | HRH4 (0.52) | MAP3K12 | |
| SCHEMBL3430562 | 0.77 | CHRNA7 (0.56) | — | |
| SCHEMBL3431228 | 0.73 | CHRNA7 (0.38) | — | |
| SCHEMBL2577774 | 0.71 | MAP3K12 (0.49) | MAP3K12MTORPIK3CA | |
| SCHEMBL22163205 | 0.69 | MAP3K12 (0.51) | MAP3K12MTORPIK3CA | |
| SCHEMBL18436556 | 0.68 | PRKDC (0.45) | MAP3K12MTORPIK3CA | |
| SCHEMBL16210488 | 0.68 | MAP3K12 (1.00) | MAP3K12 | |
| SCHEMBL7708544 | 0.68 | NOS1 (0.58) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265607-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | Rigel Pharmaceuticals, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009103032-A1 | PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES | RIGEL PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |