Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 17/20 | 0.44 |
| ▸ | CA1 | P00915 | 15/20 | 0.44 |
| ▸ | CA4 | P22748 | 6/20 | 0.44 |
| ▸ | CA7 | P43166 | 6/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 11/20 | 0.39 |
| ▸ | CA12 | O43570 | 10/20 | 0.39 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3432711 | 0.83 | MAPT (0.37) | ALDH1A1 | |
| SCHEMBL3433444 | 0.76 | ALOX5AP (0.39) | CA2CA1CA4CA7CA9 | |
| SCHEMBL6519016 | 0.71 | PTGS2 (0.45) | CA2CA1CA4CA7PTGS2 | |
| SCHEMBL28288942 | 0.70 | KDM4E (0.35) | ALDH1A1 | |
| SCHEMBL27816697 | 0.68 | CA2 (0.75) | CA2CA1CA4CA7PTGS2 | |
| SCHEMBL7504953 | 0.67 | CA2 (0.44) | CA2CA1CA4CA7PTGS2 | |
| SCHEMBL14953190 | 0.66 | CDC7 (0.43) | ALDH1A1 | |
| SCHEMBL7509654 | 0.65 | RXRA (0.46) | CA2CA1CA4CA7PTGS2 | |
| SCHEMBL14937572 | 0.63 | CA1 (0.63) | CA2CA1CA4CA7CA9 | |
| SCHEMBL3436162 | 0.63 | MAPT (0.57) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262781-A1 | NOVEL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NeuroSearch AS (DK) | 2010-12-22 | — | — | EP | claimed |
| WO-2009112459-A1 | NOVEL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2009-09-17 | — | — | WO | claimed |
| EP-2262781-A1 | NOVEL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NeuroSearch AS (DK) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009112459-A1 | NOVEL 1,2,3-TRIAZOLE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2009-09-17 | — | — | WO | disclosed |