SCHEMBL3434106

SCHEMBL3434106

CCCCOC(=O)N(C)C(C(=O)O)C(C)C

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.41
ATM Q13315 1/20 0.39
HCAR2 Q8TDS4 3/20 0.39
HPGD P15428 3/20 0.37
TSHR P16473 2/20 0.37
CHRNB2 P17787 1/20 0.35
CHRNA4 P43681 1/20 0.35
NAAA Q02083 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
TDP1 Q9NUW8 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPT P10636 1/20 0.34
MAPK1 P28482 1/20 0.34
MCL1 Q07820 1/20 0.34
PPARG P37231 2/20 0.33
PPARA Q07869 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1759122 0.83 ALDH1A1 (0.44) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL3059935 0.83 ALDH1A1 (0.44) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL5325462 0.80 ALDH1A1 (0.31) ALDH1A1HCAR2
SCHEMBL3616874 0.79 ALDH1A1 (0.47) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL5077756 0.78 ALDH1A1 (0.42) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL7375873 0.78 ALDH1A1 (0.39) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL28494423 0.77 ALDH1A1 (0.41) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL8591963 0.76 ALDH1A1 (0.38) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL5058562 0.76 ALDH1A1 (0.35) ALDH1A1ATMHCAR2HPGDTSHR
SCHEMBL31269529 0.76 ALDH1A1 (0.44) ALDH1A1ATMHCAR2HPGDTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2254883-A1 SUBSTITUTED INDOLE DERIVATIVES Grünenthal GmbH (DE) 2010-12-01 EP disclosed
WO-2009103552-A1 SUBSTITUTED INDOLE DERIVATIVES Grünenthal GmbH (DE) 2009-08-27 WO disclosed