Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD2 | P25440 | 1/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.39 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | FAP | Q12884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13013567 | 0.94 | MAOB (0.44) | BRD4BRD2BRD3BRDTMAOB | |
| SCHEMBL3433034 | 0.77 | BRD4 (0.48) | CACNA1BBRD4BRD2BRD3BRDT | |
| SCHEMBL9976375 | 0.76 | BRD4 (0.48) | BRD4BRD2BRD3BRDTMAPT | |
| SCHEMBL2725332 | 0.74 | BRD4 (0.60) | BRD4BRD2BRD3BRDTLMNA | |
| SCHEMBL13014246 | 0.73 | ADORA3 (0.42) | CACNA1CBRD4BRD2BRD3BRDT | |
| SCHEMBL13012739 | 0.73 | BRD4 (0.46) | BRD4BRD2BRD3BRDTNPSR1 | |
| SCHEMBL3434420 | 0.70 | CACNA2D1 (0.39) | CACNA2D1CACNA1BCACNB1CACNA1CMAOB | |
| SCHEMBL3434014 | 0.69 | BRD4 (0.45) | BRD4BRD2BRD3BRDTMAPT | |
| SCHEMBL3434768 | 0.68 | BRD4 (0.39) | BRD4BRD2BRD3BRDTMAPT | |
| SCHEMBL3435004 | 0.68 | BRD4 (0.48) | BRD4BRD2BRD3BRDTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |