Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13014413 | 0.73 | ALDH1A1 (0.57) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL3434370 | 0.70 | CACNA2D1 (0.40) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL13014262 | 0.67 | ALDH1A1 (0.47) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL31350717 | 0.63 | MAOB (0.80) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL13013567 | 0.63 | MAOB (0.44) | ALDH1A1MEN1KMT2AUSP2CYP3A4 | |
| SCHEMBL13014207 | 0.62 | LMNA (0.38) | ALDH1A1MEN1KMT2ATSHRMAPT | |
| SCHEMBL13013572 | 0.62 | KMT2A (0.37) | ALDH1A1MEN1KMT2AMAPTGAA | |
| SCHEMBL31350944 | 0.62 | MAOB (0.56) | CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1 | |
| SCHEMBL7247169 | 0.61 | SIGMAR1 (0.53) | ALDH1A1KMT2AMAPTGAANPSR1 | |
| SCHEMBL31023878 | 0.61 | CACNA2D1 (0.65) | CACNA2D1CACNA1BCACNB1CACNA1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010149786-A1 | PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2010-12-29 | — | — | WO | disclosed |
| EP-2266984-A1 | Pyrido[2,3-d]pyrimidines as Wnt antagonists for treatment of cancer and arthritis | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts (DE) | 2010-12-29 | — | — | EP | disclosed |