Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.51 |
| ▸ | DTYMK | P23919 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | EIF4E | P06730 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11581177 | 0.82 | CDK2 (0.55) | DTYMKAKR1C2KDM4EMEN1KMT2A | |
| SCHEMBL30566926 | 0.82 | DTYMK (0.62) | GPR35DTYMKAKR1C2AKR1C1GRIN1 | |
| SCHEMBL1228589 | 0.82 | DTYMK (0.62) | GPR35DTYMKAKR1C2AKR1C1GRIN1 | |
| SCHEMBL132963 | 0.82 | GPR35 (0.50) | GPR35DTYMKAKR1C2AKR1C1KDM4E | |
| SCHEMBL14503732 | 0.81 | DTYMK (0.46) | GPR35DTYMKKDM4EMEN1KMT2A | |
| SCHEMBL27745774 | 0.80 | GPR35 (0.49) | GPR35DTYMKAKR1C2AKR1C1KDM4E | |
| SCHEMBL28588348 | 0.79 | AKR1C3 (0.54) | AKR1C2AKR1C1KDM4EMEN1KMT2A | |
| SCHEMBL8147367 | 0.76 | TSHR (0.43) | KDM4EMEN1KMT2ATSHR | |
| SCHEMBL8155350 | 0.76 | TSHR (0.43) | KDM4EMEN1KMT2ATSHR | |
| SCHEMBL11697530 | 0.75 | DTYMK (0.60) | GPR35DTYMKTSHRCASP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8476454-B2 | IDO inhibitors and methods of use | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-07-02 | — | — | US | disclosed |
| US-20100233166-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | PRENDERGAST GEORGE C | 2010-09-16 | — | — | US | disclosed |
| US-7714139-B2 | IDO inhibitors and methods of use | LANKENAU INSTITUTE FOR MEDCIAL RESEARCH (US) | 2010-05-11 | — | — | US | disclosed |
| EP-1606285-A4 | NOVEL IDO INHIBITORS AND METHODS OF USE | LANKENAU INST MEDICAL RES (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20070173524-A1 | \"Novel ido inhibitors and methods of use | LANKENAU INSTITUTE FOR MEDICAL RESEARCH | 2007-07-26 | — | — | US | disclosed |
| EP-1606285-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | Lankenau Institute for Medical Research (US) | 2005-12-21 | — | — | EP | disclosed |
| WO-2004094409-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2004-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173524-A1 | \"Novel ido inhibitors and methods of use | IDO1, IDO2, INMT | GPR35 1927/4885DTYMK 27/4885AKR1C2 1865/4885 |
| US-20100233166-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE | IDO1, IDO2, INMT | GPR35 2230/4885DTYMK 30/4885AKR1C2 2129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.