Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | XBP1 | P17861 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17068942 | 0.89 | TAAR1 (0.56) | TDP1LMNAALDH1A1GAAHPGD | |
| SCHEMBL371244 | 0.89 | TAAR1 (0.56) | TDP1LMNAALDH1A1GAAHPGD | |
| Hydrochloric Acid SCHEMBL7988601 | 0.86 | TAAR1 (0.54) | TDP1LMNAALDH1A1GAAHPGD | |
| Ammonia Solution, Strong SCHEMBL6187599 | 0.86 | TAAR1 (0.54) | TDP1LMNAALDH1A1GAAHPGD | |
| SCHEMBL4846241 | 0.83 | LMNA (0.54) | TDP1LMNAALDH1A1GAAHPGD | |
| Dimethylamine SCHEMBL4661334 | 0.82 | TAAR1 (0.61) | TDP1LMNAALDH1A1GAAHPGD | |
| SCHEMBL8511928 | 0.82 | TAAR1 (0.56) | TDP1LMNAALDH1A1GAAHPGD | |
| SCHEMBL7552100 | 0.82 | MAOB (0.59) | TDP1LMNAALDH1A1GAAHPGD | |
| Acetic Acid SCHEMBL27813854 | 0.82 | ALDH1A1 (0.61) | TDP1ALDH1A1GAAHPGDFFAR1 | |
| SCHEMBL4115930 | 0.81 | GAA (0.61) | TDP1LMNAALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051980-B1 | Dopamine transporter imaging agents | HARVARD COLLEGE (US) | 2010-12-15 | — | — | EP | claimed |