SCHEMBL3434860

SCHEMBL3434860

O=C(O)n1nc(-c2cc(Cl)ccc2Cl)cc1CBr

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
TP53 P04637 1/20 0.38
RORC P51449 3/20 0.37
IDO1 P14902 1/20 0.36
PKM P14618 1/20 0.36
ERCC5 P28715 1/20 0.35
FEN1 P39748 1/20 0.35
CNR1 P21554 2/20 0.35
MEN1 O00255 1/20 0.35
POLB P06746 1/20 0.35
KMT2A Q03164 1/20 0.35
CNR2 P34972 1/20 0.35
MAPT P10636 1/20 0.34
HPGD P15428 1/20 0.34
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
HSD17B10 Q99714 1/20 0.34
APOBEC3G Q9HC16 1/20 0.34
BACE1 P56817 1/20 0.33
PTPN11 Q06124 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3394445 0.85 ALPL (0.43) ALDH1A1TP53MEN1KMT2AMAPT
SCHEMBL13425822 0.82 ROCK2 (0.37) ALDH1A1RORCIDO1PKMCNR1
SCHEMBL3431052 0.79 CNR1 (0.37) ALDH1A1TP53CNR1MEN1KMT2A
SCHEMBL3432882 0.76 HSP90AA1 (0.41) CNR1POLB
SCHEMBL3395670 0.73 SORT1 (0.32) ALDH1A1MAPTHPGD
SCHEMBL13425449 0.72 CNR1 (0.42) ALDH1A1CNR1CNR2MAPT
SCHEMBL3395630 0.70 HDAC6 (0.44) ALDH1A1MEN1KMT2AMAPT
SCHEMBL3394902 0.70 GSK3B (0.39) RXRARXRB
SCHEMBL13425876 0.68 NPC1 (0.38) CNR1CNR2HPGD
SCHEMBL3395627 0.68 ALPL (0.47) ALDH1A1KMT2AHPGDHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed