Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 9/20 | 0.34 |
| ▸ | NAMPT | P43490 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BCL9 | O00512 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6518971 | 0.87 | BCL9 (0.36) | ALDH1A1LMNATDP1PROKR1NAMPT | |
| SCHEMBL3410172 | 0.83 | PROKR1 (0.38) | ALDH1A1LMNATDP1PROKR1NPC1 | |
| SCHEMBL3435244 | 0.74 | PDE4B (0.39) | ALDH1A1PROKR1NAMPTBCL9CTNNB1 | |
| SCHEMBL6519249 | 0.69 | PDE4B (0.42) | ALDH1A1LMNAPDE4B | |
| SCHEMBL4099888 | 0.65 | RAB9A (0.57) | ALDH1A1LMNAPROKR1NPC1RAB9A | |
| SCHEMBL1422381 | 0.61 | PARP1 (0.49) | BCL9CTNNB1PDE4B | |
| SCHEMBL30158182 | 0.61 | PARP1 (0.56) | — | |
| SCHEMBL9509660 | 0.61 | PROKR1 (0.60) | ALDH1A1LMNAPROKR1NPC1RAB9A | |
| SCHEMBL3660445 | 0.60 | PARP1 (0.69) | — | |
| SCHEMBL16322554 | 0.60 | PARP1 (0.69) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265611-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009112832-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-09-17 | — | — | WO | disclosed |