Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PROKR1 | Q8TCW9 | 9/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | BCL9 | O00512 | 2/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6519249 | 0.86 | PDE4B (0.42) | PDE4BJAK1JAK2ALDH1A1 | |
| SCHEMBL3435942 | 0.74 | ALDH1A1 (0.35) | PDE4BPROKR1BCL9CTNNB1NAMPT | |
| SCHEMBL3410172 | 0.72 | PROKR1 (0.38) | PROKR1ALDH1A1 | |
| SCHEMBL23040449 | 0.71 | LMNA (0.49) | PDE4BPROKR1BCL9CTNNB1MEN1 | |
| SCHEMBL31386328 | 0.69 | NPC1 (0.42) | PDE4BPROKR1BCL9CTNNB1KDM4E | |
| SCHEMBL6518971 | 0.69 | BCL9 (0.36) | PROKR1BCL9CTNNB1NAMPTALDH1A1 | |
| SCHEMBL6523422 | 0.69 | POLB (0.42) | PDE4BJAK1JAK2 | |
| SCHEMBL3413163 | 0.68 | CA12 (0.41) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL3434006 | 0.68 | POLB (0.38) | PDE4BMEN1ALDH1A1KMT2A | |
| SCHEMBL3434005 | 0.68 | POLB (0.38) | PDE4BMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265611-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2010-12-29 | — | — | EP | disclosed |
| WO-2009112832-A1 | TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2009-09-17 | — | — | WO | disclosed |