Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11123891 | 0.84 | ALDH1A1 (0.52) | ALDH1A1ALOX15MAPTHDAC8SMN1; SMN2 | |
| SCHEMBL9812570 | 0.78 | MAPT (0.61) | ALDH1A1ALOX15MAPTHDAC8SMN1; SMN2 | |
| SCHEMBL30231535 | 0.76 | KDM4E (0.60) | ALDH1A1ALOX15MAPTSMN1; SMN2HPGD | |
| SCHEMBL928902 | 0.76 | KDM4E (0.60) | ALDH1A1ALOX15MAPTSMN1; SMN2HPGD | |
| SCHEMBL3328547 | 0.76 | ALDH1A1 (0.44) | ALDH1A1ALOX15MAPTHDAC8SMN1; SMN2 | |
| SCHEMBL4804676 | 0.74 | ALDH1A1 (0.42) | ALDH1A1ALOX15MAPTSMN1; SMN2HPGD | |
| SCHEMBL367697 | 0.74 | ERCC5 (0.53) | ALDH1A1ALOX15SMN1; SMN2HPGDKDM4E | |
| SCHEMBL6472175 | 0.74 | MEN1 (0.50) | ALDH1A1ALOX15MAPTHDAC8SMN1; SMN2 | |
| SCHEMBL10346045 | 0.74 | CES2 (0.58) | ALDH1A1ALOX15MAPTHPGDLMNA | |
| SCHEMBL7118618 | 0.74 | MAPT (0.55) | ALDH1A1ALOX15MAPTSMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150141470-A1 | DIAGNOSTIC AND TREATMENT METHODS IN PATIENTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY | THE BROAD INSTITUTE, INC. (US) | 2015-05-21 | — | — | US | disclosed |
| WO-2013169858-A1 | DIAGNOSTIC AND TREATMENT METHODS IN PATIENTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY | THE BROAD INSTITUTE, INC. (US) | 2013-11-14 | — | — | WO | disclosed |
| US-7807400-B2 | Methods for identifying chemical modulators of Ras superfamily GTPase activity | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-10-05 | — | — | US | disclosed |
| US-20080027135-A1 | Methods For Identifying Chemical Modulators Of Ras Superfamily Gptase Activity | NORTH CAROLINA AT CHAPEL HILL, UNIVERSITY OF | 2008-01-31 | — | — | US | disclosed |
| WO-2005115482-A2 | METHODS FOR IDENTIFYING CHEMICAL MODULATORS OF RAS SUPERFAMILY GTPASE ACTIVITY | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2005-12-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150141470-A1 | DIAGNOSTIC AND TREATMENT METHODS IN PATIENTS HAVING OR AT RISK OF DEVELOPING RESISTANCE TO CANCER THERAPY | HDAC7, HDAC9, MAPK4 | ALDH1A1 2143/4885ALOX15 4417/4885MAPT 3347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.