SCHEMBL3438971

SCHEMBL3438971

Cc1ccc(C(=O)OCC(=O)OCCCOC(=O)COC(=O)c2ccc(N)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 4/20 0.59
▸ CYP1A2 P05177 4/20 0.59
▸ CYP3A4 P08684 3/20 0.59
▸ TSHR P16473 3/20 0.59
▸ CYP2C19 P33261 2/20 0.59
▸ CYP2C9 P11712 1/20 0.59
▸ PDE4D Q08499 1/20 0.59
▸ MAOA P21397 2/20 0.57
▸ RAB9A P51151 6/20 0.56
▸ NPC1 O15118 4/20 0.56
▸ MAPT P10636 2/20 0.56
▸ ALDH1A1 P00352 2/20 0.56
▸ TDP1 Q9NUW8 2/20 0.51
▸ CYP2D6 P10635 3/20 0.51
▸ SCN1A P35498 2/20 0.51
▸ SCN2A Q99250 2/20 0.51
▸ SCN3A Q9NY46 2/20 0.51
▸ CHRM2 P08172 1/20 0.51
▸ HTR1A P08908 1/20 0.51
▸ GAA P10253 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3438973 0.97 RAB9A (0.60) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL3438972 0.94 LMNA (0.60) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL10301408 0.92 LMNA (0.63) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL15908151 0.92 TDP1 (0.58) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL3438975 0.90 LMNA (0.55) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL15908119 0.89 RAB9A (0.57) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL10301414 0.89 NPC1 (0.64) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL10301412 0.86 LMNA (0.59) LMNACYP1A2CYP3A4TSHRCYP2C19
SCHEMBL15908100 0.86 RAB9A (0.60) LMNACYP1A2CYP3A4MAOARAB9A
SCHEMBL3438974 0.84 LMNA (0.55) LMNACYP1A2CYP3A4TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160023998-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS BEZWADA BIOMEDICAL LLC (US) 2016-01-28 — — US disclosed
US-9174924-B2 Hydrolysable linkers and cross-linkers for absorbable polymers BEZWADA BIOMEDICAL, LLC (US) 2015-11-03 — — US disclosed
US-20150259275-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS BEZWADA BIOMEDICAL LLC (US) 2015-09-17 — — US disclosed
US-9045396-B2 Hydrolysable linkers and cross-linkers for absorbable polymers BEZWADA BIOMEDICAL, LLC (US) 2015-06-02 — — US disclosed
US-20140163253-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS BEZWADA BIOMEDICAL, LLC (US) 2014-06-12 — — US disclosed
US-8664429-B2 Hydrolysable linkers and cross-linkers for absorbable polymers BEZWADA BIOMEDICAL, LLC (US) 2014-03-04 — — US disclosed
US-20130310596-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS BEZWADA BIOMEDICAL, LLC (US) 2013-11-21 — — US disclosed
US-8399696-B2 Functionalized biodegradable triclosan monomers and oligomers for controlled release BEZWADA BIOMEDICAL, LLC (US) 2013-03-19 — — US disclosed
US-20120289614-A1 FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE BEZWADA BIOMEDICAL, LLC (US) 2012-11-15 — — US disclosed
US-20120197037-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS BEZWADA BIOMEDICAL, LLC (US) 2012-08-02 — — US disclosed
US-8232422-B2 Functionalized biodegradable triclosan monomers and oligomers for controlled release BEZWADA BIOMEDICAL, LLC (US) 2012-07-31 — — US disclosed
US-20120095114-A1 FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE BEZWADA BIOMEDICAL, LLC (US) 2012-04-19 — — US disclosed
US-8053591-B2 Functionalized biodegradable triclosan monomers and oligomers for controlled release BEZWADA BIOMEDICAL, LLC (US) 2011-11-08 — — US disclosed
US-8048980-B2 Hydrolysable linkers and cross-linkers for absorbable polymers BEZWADA BIOMEDICAL, LLC (US) 2011-11-01 — — US disclosed
US-20090105352-A1 FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE BEZWADA BIOMEDICAL, LLC (US) 2009-04-23 — — US disclosed
US-20090082540-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS BEZWADA BIOMEDICAL, LLC (US) 2009-03-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150259275-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS SI, KDM8, APEH LMNA 2710/4885CYP1A2 1323/4885CYP3A4 1200/4885
US-20120197037-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS SI, KDM8, APEH LMNA 2710/4885CYP1A2 1323/4885CYP3A4 1200/4885
US-20090105352-A1 FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE LTN1, PARN, TLR3 LMNA 806/4885CYP1A2 1940/4885CYP3A4 984/4885
US-20090082540-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS SI, KDM8, APEH LMNA 2710/4885CYP1A2 1323/4885CYP3A4 1200/4885
US-20120095114-A1 FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE LTN1, PARN, TLR3 LMNA 806/4885CYP1A2 1940/4885CYP3A4 984/4885
US-20160023998-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS SI, KDM8, APEH LMNA 2710/4885CYP1A2 1323/4885CYP3A4 1200/4885
US-20120289614-A1 FUNCTIONALIZED BIODEGRADABLE TRICLOSAN MONOMERS AND OLIGOMERS FOR CONTROLLED RELEASE LTN1, PARN, TLR3 LMNA 806/4885CYP1A2 1940/4885CYP3A4 984/4885
US-20130310596-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS SI, KDM8, APEH LMNA 2710/4885CYP1A2 1323/4885CYP3A4 1200/4885
US-20140163253-A1 HYDROLYSABLE LINKERS AND CROSS-LINKERS FOR ABSORBABLE POLYMERS SI, KDM8, APEH LMNA 2710/4885CYP1A2 1323/4885CYP3A4 1200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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