Sugi Predict

Sugi Predict / Compounds / SCHEMBL34403

SCHEMBL34403

SCHEMBL34403

Clc1cccc(C(Cl)(c2ccccc2)c2ccccc2)c1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KIF11 P52732 6/20 0.49
▸ TSHR P16473 4/20 0.44
▸ CYP19A1 P11511 4/20 0.42
▸ ALDH1A1 P00352 1/20 0.39
▸ ACP3 P15309 1/20 0.39
▸ NPC1 O15118 2/20 0.37
▸ RAB9A P51151 2/20 0.37
▸ MEN1 O00255 1/20 0.37
▸ LMNA P02545 1/20 0.37
▸ MAPT P10636 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ KMT2A Q03164 1/20 0.37
▸ SIGMAR1 Q99720 1/20 0.37
▸ TP53 P04637 1/20 0.37
▸ NFKB1 P19838 1/20 0.37
▸ NFKB2 Q00653 1/20 0.37
▸ RELA Q04206 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30791489 1.00 KIF11 (0.49) KIF11TSHRCYP19A1ALDH1A1ACP3
SCHEMBL9332683 0.93 CYP19A1 (0.46) KIF11TSHRCYP19A1ALDH1A1MEN1
SCHEMBL13957446 0.89 KIF11 (0.41) KIF11TSHRCYP19A1ALDH1A1MEN1
SCHEMBL12305489 0.87 CYP19A1 (0.52) KIF11TSHRCYP19A1ALDH1A1MEN1
SCHEMBL11874464 0.85 TSHR (0.52) KIF11TSHRCYP19A1ALDH1A1ACP3
SCHEMBL11862867 0.82 KIF11 (0.49) KIF11TSHRCYP19A1ALDH1A1NPC1
Chlorotriphenylmethane SCHEMBL16781670 0.80 TSHR (0.65) TSHRCYP19A1ALDH1A1CYP1A2
Chlorotriphenylmethane SCHEMBL461 0.80 TSHR (0.65) TSHRCYP19A1ALDH1A1CYP1A2
SCHEMBL20272580 0.79 KIF11 (0.43) KIF11ALDH1A1NPC1RAB9AMEN1
SCHEMBL9549019 0.79 KIF11 (0.50) KIF11TSHRCYP19A1ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250127797-A1 PRODRUG COMPRISING A DRUG-LINKER CONJUGATE ASCENDIS PHARMA A/S (DK) 2025-04-24 — — US disclosed
CN-117630242-A Method for separating and detecting impurity a in clotrimazole intermediate by high performance liquid chromatography 重庆华邦制药有限公司 2024-03-01 — — CN disclosed
US-20240041897-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE ASCENDIS PHARMA GMBH (DE) 2024-02-08 — — US disclosed
US-20220331334-A1 Prodrug Comprising a Drug-Linker Conjugate ASCENDIS PHARMA A/S (DK) 2022-10-20 — — US disclosed
EP-3981761-A2 INTERMEDIATES FOR PRODRUGS Ascendis Pharma A/S (DK) 2022-04-13 — — EP disclosed
EP-2596805-B1 Prodrug comprising a drug-linker conjugate ASCENDIS PHARMA AS (DK) 2021-10-27 — — EP disclosed
US-20200046725-A1 Prodrug Comprising a Drug Linker Conjugate ASCENDIS PHARMA A/S (DK) 2020-02-13 — — US disclosed
EP-2237799-B1 PRODRUG COMPRISING A SELF-CLEAVABLE LINKER ASCENDIS PHARMA AS (DK) 2019-04-10 — — EP disclosed
US-20170100490-A1 Prodrug Comprising a Drug Linker Conjugate ASCENDIS PHARMA A/S (DK) 2017-04-13 — — US disclosed
US-20150057221-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE ASCENDIS PHARMA AS (DK) 2015-02-26 — — US disclosed
US-8906847-B2 Prodrug comprising a drug linker conjugate ASCENDIS PHARMA A/S (DK) 2014-12-09 — — US disclosed
CN-101980725-B Prodrug comprising a drug linker conjugate ASCENDIS PHARMA AS 2013-06-12 — — CN disclosed
EP-2596805-A1 Prodrug comprising a drug linker conjugate Ascendis Pharma A/S (DK) 2013-05-29 — — EP disclosed
US-20110053848-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE ASCENDIS PHARMA AS (DK) 2011-03-03 — — US disclosed
CN-101980725-A Prodrug comprising a drug linker conjugate ASCENDIS PHARMA AS 2011-02-23 — — CN disclosed
WO-2011012723-A1 INJECTABLE SUSTAINED RELEASE COMPOSITIONS COMPRISING A PRAMIPEXOLE PRODRUG ASCENDIS PHARMA AS (DK) 2011-02-03 — — WO disclosed
EP-2237799-A2 PRODRUG COMPRISING A SELF-CLEAVABLE LINKER Ascendis Pharma AS (DK) 2010-10-13 — — EP disclosed
US-20090227467-A1 COMBINATORIAL ROSAMINE LIBRARY TO DETECT CELL-STATE SWITCHING NEW YORK UNIVERSITY (US) 2009-09-10 — — US disclosed
WO-2009095479-A2 PRODRUG COMPRISING A SELF-CLEAVABLE LINKER ASCENDIS PHARMA AS (DK) 2009-08-06 — — WO disclosed
US-3934022-A N-trityl-imidazoles as plant fungicides BAYER AKTIENGESELLSCHAFT (DT) 1976-01-20 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150057221-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE H1-0, H1-3, H1-2 KIF11 3253/4885TSHR 991/4885CYP19A1 329/4885
US-20170100490-A1 Prodrug Comprising a Drug Linker Conjugate H1-0, H1-3, H1-2 KIF11 3253/4885TSHR 991/4885CYP19A1 329/4885
US-20110053848-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE H1-0, H1-3, H1-2 KIF11 3244/4885TSHR 997/4885CYP19A1 328/4885
US-20200046725-A1 Prodrug Comprising a Drug Linker Conjugate H1-0, H1-3, H1-2 KIF11 3221/4885TSHR 994/4885CYP19A1 328/4885
US-20240041897-A1 PRODRUG COMPRISING A DRUG LINKER CONJUGATE H1-0, H1-3, H1-2 KIF11 3253/4885TSHR 991/4885CYP19A1 329/4885
US-20220331334-A1 Prodrug Comprising a Drug-Linker Conjugate H1-0, H1-3, DLST KIF11 3239/4885TSHR 1240/4885CYP19A1 373/4885
US-20250127797-A1 PRODRUG COMPRISING A DRUG-LINKER CONJUGATE H1-0, H1-3, DLST KIF11 3239/4885TSHR 1240/4885CYP19A1 373/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.