Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24196541 | 0.85 | CHRM5 (0.48) | CHRM5ADRA2CACHEL3MBTL1L3MBTL3 | |
| SCHEMBL24197230 | 0.82 | CHRM5 (0.45) | CHRM5ADRA2CACHEL3MBTL1SMN1; SMN2 | |
| SCHEMBL14958747 | 0.82 | CHRM5 (0.41) | CHRM5ADRA2CACHEL3MBTL1L3MBTL3 | |
| SCHEMBL2547787 | 0.81 | CHRM5 (0.39) | CHRM5ADRA2CACHESMN1; SMN2OPRM1 | |
| SCHEMBL22518683 | 0.81 | ACHE (0.42) | CHRM5ADRA2CACHEL3MBTL1L3MBTL3 | |
| SCHEMBL13247682 | 0.81 | CHRM5 (0.39) | CHRM5ADRA2CACHEOPRM1OPRL1 | |
| SCHEMBL13247999 | 0.81 | ACHE (0.62) | CHRM5ADRA2CACHEOPRM1OPRL1 | |
| SCHEMBL10293571 | 0.80 | CHRM5 (0.58) | CHRM5ADRA2CACHESMN1; SMN2ALDH1A1 | |
| SCHEMBL2225387 | 0.80 | — | — | |
| SCHEMBL2225393 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402329-A1 | Analgetic phenylsulphonamides | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| EP-2284166-A1 | Arylsulfonamides with analgetic activity | Boehringer Ingelheim International GmbH (DE) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009021758-A1 | ARYLSULFONAMIDES HAVING AN ANALGESIC EFFECT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-02-19 | — | — | WO | disclosed |
| EP-2025675-A1 | Arylsulfonamides with analgetic activity | Boehringer Ingelheim International GmbH (DE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008022945-A1 | ARYL SULFONAMIDES WITH AN ANALGESIC ACTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-02-28 | — | — | WO | disclosed |